Mesenchymal Stem Cell Bioreactor for the Active Treatment of Acute Renal Failure

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$773,285.00
Award Year:
2012
Program:
SBIR
Phase:
Phase II
Contract:
2R44DK085766-03
Award Id:
n/a
Agency Tracking Number:
R44DK085766
Solicitation Year:
2012
Solicitation Topic Code:
NIDDK
Solicitation Number:
PA11-096
Small Business Information
196 Boston Ave, Medford, MA, 02155
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
828970900
Principal Investigator:
ARNOTILLES
(617) 724-2953
arno.tilles@sentienbiotech.com
Business Contact:
BRIANMILLER
(781) 361-9031
brian.miller@sentienbiotech.com
Research Institute:
Stub




Abstract
DESCRIPTION (provided by applicant): The overall goal of this project is to design a clinical protocol for the operation and monitoring of a mesenchymal stem cell (MSC)-coated dialysis device for the treatment of acute renal failure (ARF) in dogs. The project specific aims are: (1) Biomarker-guided initiation of Sentinel therapy in an ARF dogs. (2) Execute a dose escalation trial of the Sentinel in ARF dogs. The deliverable of this completed project will be an IND-ready device therapy that will be advancingtowards a Phase I clinical study. PUBLIC HEALTH RELEVANCE: Sentien Biotechnologies, Inc. has developed a mesenchymal stem cell (MSC)-coated device that offers combinatorial therapeutic support to patients undergoing acute renal failure (ARF). Thedevice delivers MSC-derived secretions of anti-inflammatory and regenerative molecules directly into the bloodstream in a dynamic and sustained manner. We now plan to develop an effective clinical protocol for the device for ARF that captures the criticalcomponents of a administering a new drug, namely (i) initiation time, (i) dose, and (iii) duration of treatment that will enable human investigation.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government