Catechol-functionalized Coatings for Medical Devices

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 2R44HL093928-02
Agency Tracking Number: R44HL093928
Amount: $999,107.00
Phase: Phase II
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: NHLBI
Solicitation Number: PA11-096
Small Business Information
1000 WESTGATE DR, STE 115, ST. PAUL, MN, -
DUNS: 148070860
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (651) 209-9757
Business Contact
Phone: (651) 209-9757
Research Institution
DESCRIPTION (provided by applicant): This project is designed to develop novel catechol-functionalized polymers for medical device coatings with increased lubricity and biocompatibility. Catechols have been shown to be key components in the adhesive proteins that mussels secrete to attach to underwater surfaces. The catechol has a number of different non-covalent bond interactions which serve to increase adherence of catechol-functionalized molecules to both organic and inorganic substrates. This ability will be utilized to create coatings that adhere to previously difficult-to-coat medical device materials such as silicone, PEBAX- 72 and HDPE, opening the way to enhanced device properties for these materials. In Phase I, catechols were incorporated by synthesizing a catechol monomer and copolymerizing with vinyl pyrrolidone, a commonly used hydrogel coating for increasing the slipperiness of a coating. While catechols had previously been attached to other polymers, they have been limited primarily to poly(ethylene glycol). The innovation in this proposal lies in the development of catechol-functionalized polymers for improved lubricity coatings for medical devices. In Phase II, the catechol-functionalized polymers will be optimized, applied to two commercialmedical devices (cardiovascular radial introducer and a cerebrospinal shunt) that lack adherent coatings, and expanded to include hemocompatible, passivating, and non-oxidant reliant copolymers. PUBLIC HEALTH RELEVANCE: This proposal will develop coatings for medical devices to increase slipperiness and compatibility with the body. It targets specific materials used in the device fabrication which are difficult to coat with a novel approach inspired by mussels. These mussel- inspired coatings shouldallow easier insertion of medical devices with less tissue injury and pain. The proposal specifically targets a cardiovascular device (radial introducer) and a neurological device (cerebrospinal shunts). Improved medical devices will improve patient comfort and health.

* information listed above is at the time of submission.

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