High Specific Activity Sm-153 by Post Irradiation Isotope Separation

Award Information
Agency: Department of Energy
Branch: N/A
Contract: DE-FG02-11ER90169
Agency Tracking Number: 97861
Amount: $989,748.00
Phase: Phase II
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: 46 b
Solicitation Number: DE-FOA-0000676
Small Business Information
1004 S. Velasco, Angleton, TX, 77515-5250
DUNS: 621139976
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Jaime Simon
 (979) 848-0800
Business Contact
 R Frank
Title: Dr.
Phone: (979) 848-0800
Email: keithfrank@isotherapeutics.com
Research Institution
Samarium-153 (153Sm) has ideal nuclear properties for a variety of therapeutic applications; however, it is only available in low specific activity (radioactivity/weight) form. While large quantities can be made by the 152Sm(n,)153Sm reaction in a medium flux reactor such as at the University of Missouri Research Reactor Center (MURR), typical irradiation parameters result in less than 2% of the 152Sm target material being converted into 153Sm. Since chemical methods cannot be used to perform isotopic separation, this means that & gt;98% of the resultant pharmaceutical molecules are labeled with cold atoms and are therefore incapable of delivering the desired radiation-induced therapeutic effect. Electromagnetic isotope separation is routinely used in the production of enriched stable isotopes and in mass spectrometry; however, the successful development of an economically viable facility for processing relatively short-lived radioactive medical isotopes presents new challenges. Results of the Phase I project clearly indicate the technical feasibility of using this approach for processing 153Sm. Experimental ion source testing demonstrated high extracted Sm+ ion current, in excess of 1 mA. All key process steps were tested individually, including pre- and post- separation chemistry.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government