Platform for myocardial infarct MRI and delivery of therapeutics

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$379,160.00
Award Year:
2012
Program:
STTR
Phase:
Phase I
Contract:
1R41HL116014-01
Award Id:
n/a
Agency Tracking Number:
R41HL116014
Solicitation Year:
2012
Solicitation Topic Code:
NHLBI
Solicitation Number:
PA11-097
Small Business Information
603 STANWIX STREET, SUITE 348, PITTSBURGH, PA, 15222-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
798793548
Principal Investigator:
ERIC AHRENS
(412) 268-5105
eta@celsense.com
Business Contact:
AMY WESA
(412) 263-2870
awesa@celsense.com
Research Institution:
CELSENSE, INC.

603 STANWIX STREET
SUITE 348
PITTSBURGH, PA, 15222-
() -
Domestic nonprofit research organization
Abstract
Myocardial infarction (MI) afflicts more than one million persons per year in the United States alone. MI results in permanent left ventricle (LV) scarring that causes diminished pump efficiency and, commonly, heart failure. Towards reduction or elimination of scarring, there is increasing interest in reparative biological materials, such as cells and proteins, that are introduced into the affected region of the LV early after MI. We believe that such an approach will eventually become part of a standard ofcare. The most promising route for the delivery of such materials is direct LV injection (DLVI). Thus far, the utility of DLVI has been hampered by the lack methods for accurate spatial targeting of affected tissue. This has greatly impeded clinical translation of promising materials. The goal of this project is to devise cutting edge imaging tools to visualize infarcted regions using MRI.

* information listed above is at the time of submission.

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