SBIR Phase I: A Perfusable, Revascularized, Cardiac-Derived Patch for the Treatment of Heart Disease

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 1142525
Agency Tracking Number: 1142525
Amount: $150,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: BC
Solicitation Number: N/A
Small Business Information
18683 Bearpath Trail, Eden Prairie, MN, 55347-3476
DUNS: 965529436
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Jeffrey Ross
 (612) 202-7026
Business Contact
 Jeffrey Ross
Phone: (612) 202-7026
Research Institution
This Small Business Innovations Research (SBIR) Phase I proposal is to demonstrate the feasibility of using Miromatrix' perfusion decellularization technology to create a fully revascularized cardiac patch for the treatment of ischemic heart disease and congenital heart repair. While medical advancements have decreased the overall mortality rate for acute myocardial infarction (MI) patients, therapeutic options are lacking to address the underlying loss of myocardial tissue, resulting in a mortality rate greater than 33% at five years. For congenital repair, current surgical approaches for cardiac reconstruction utilize synthetic materials that do not have the ability to grow and remodel with the patient. The proposed cardiac-derived revascularized cardiac patch may promote faster reconstruction of functional tissue by providing a fully perfusable scaffold with a composition and architecture similar to native cardiac tissue. The broader/commercial impacts of this research are the development of a revascularized cardiac patch to treat ischemic heart failure and congenital repair. Inhibiting the onset or delaying the severity of heart failure will have a significant effect on reducing the treatment cost of heart failure, which currently is estimated at over $37 billion. This product with have significant advantages over existing technologies, including: 1) full thickness, biological, cardiac-derived matrix material; 2) vascular supply to support migrating cells and remodeling; 3) superior mechanical properties; and, 4) no need for immunosuppressive therapies. Moreover, this will be the first cardiac-derived, revascularized patch available for treating ischemic areas of the heart.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government