Design Automation Software for Biomimetic Surface Presentation with DNA Origami

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911SR-13-C-0019
Agency Tracking Number: C122-103-0003
Amount: $150,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: CBD12-103
Solicitation Number: 2012.2
Small Business Information
Parabon NanoLabs, Inc.
11260 Roger Bacon Drive, Suite 406, Reston, VA, -
DUNS: 828881305
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Steven Armentrout
 President&CEO
 (703) 689-9689
 steve@parabon.com
Business Contact
 Paula Gawthorp-Armentrout
Title: VP&Corporate Secretary
Phone: (703) 689-9689
Email: paula@parabon.com
Research Institution
 Stub
Abstract
A development program is proposed for a design automation software package that enables the generation of complex surfaces, with user defined or automated definition of point charge and hydrophobic/hydrophilic properties, using DNA origami as a presentation substrate. Building upon existing software for DNA origami design, this project will result in software able to optimize DNA staples and other origami modifications to achieve target charge and hydration force distributions. The objects to be generated with this software will be able to mimic any of the many surface/surface interactions found in biological or technological applications. Such design software will significantly expand the capabilities of users to produce systems that are capable of highly specific interactions with target macromolecular species.

* information listed above is at the time of submission.

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