Design Automation Software for Biomimetic Surface Presentation with DNA Origami
Department of Defense
Office for Chemical and Biological Defense
Agency Tracking Number:
Solicitation Topic Code:
Small Business Information
Parabon NanoLabs, Inc.
11260 Roger Bacon Drive, Suite 406, Reston, VA, -
Socially and Economically Disadvantaged:
AbstractA development program is proposed for a design automation software package that enables the generation of complex surfaces, with user defined or automated definition of point charge and hydrophobic/hydrophilic properties, using DNA origami as a presentation substrate. Building upon existing software for DNA origami design, this project will result in software able to optimize DNA staples and other origami modifications to achieve target charge and hydration force distributions. The objects to be generated with this software will be able to mimic any of the many surface/surface interactions found in biological or technological applications. Such design software will significantly expand the capabilities of users to produce systems that are capable of highly specific interactions with target macromolecular species.
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