Design Automation Software for Biomimetic Surface Presentation with DNA Origami

Award Information
Agency:
Department of Defense
Branch
Office for Chemical and Biological Defense
Amount:
$150,000.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
W911SR-13-C-0019
Award Id:
n/a
Agency Tracking Number:
C122-103-0003
Solicitation Year:
2012
Solicitation Topic Code:
CBD12-103
Solicitation Number:
2012.2
Small Business Information
11260 Roger Bacon Drive, Suite 406, Reston, VA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
828881305
Principal Investigator:
StevenArmentrout
President&CEO
(703) 689-9689
steve@parabon.com
Business Contact:
PaulaGawthorp-Armentrout
VP&Corporate Secretary
(703) 689-9689
paula@parabon.com
Research Institute:
Stub




Abstract
A development program is proposed for a design automation software package that enables the generation of complex surfaces, with user defined or automated definition of point charge and hydrophobic/hydrophilic properties, using DNA origami as a presentation substrate. Building upon existing software for DNA origami design, this project will result in software able to optimize DNA staples and other origami modifications to achieve target charge and hydration force distributions. The objects to be generated with this software will be able to mimic any of the many surface/surface interactions found in biological or technological applications. Such design software will significantly expand the capabilities of users to produce systems that are capable of highly specific interactions with target macromolecular species.

* information listed above is at the time of submission.

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