Improved Dried Biological Specimen Materials, Recovery and Processing for Diagnostics

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W31P4Q-12-C-0025
Agency Tracking Number: 11SB2-0114
Amount: $149,665.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2011
Solicitation Topic Code: SB112-005
Solicitation Number: 2011.2
Small Business Information
Connecticut Analytical Corporation
696 Amity Road, Route 63, Bethany, CT, -
DUNS: 783630189
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Joseph Bango
 President
 (203) 393-9666
 jbango@ctanalytical.com
Business Contact
 Joseph Bango
Title: President
Phone: (203) 393-9666
Email: jbango@ctanalytical.com
Research Institution
 Stub
Abstract
Dried blood spot (DBS) analysis has gained recognition in recent years in basic science and clinical diagnostics. This impetus relies upon its numerous advantages over the collection, transport and storage of blood samples obtained by conventional venipuncture. Although there is wide-spread interest in DBS, optimization of sample collection and extraction methods, as well as, the subsequent analyses by standard analytical methods is still in its infancy. Therefore, preliminary experiments comparing different extraction methods (e.g. alcohol incubation and electrospray transfer) were carried out and analyzed by enzyme linked immunosorbent assay (ELISA). We propose that electrospray ionization-transfer offers superior extraction to that of the standard chemical methods by 1) efficient extraction of analytes from the DBS substrate and 2) concentration of the analyte.

* information listed above is at the time of submission.

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