Multifunctional Stabilization Matrix for Biological Samples

Award Information
Agency:
Department of Defense
Branch:
Defense Advanced Research Projects Agency
Amount:
$99,962.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
W31P4Q-12-C-0023
Agency Tracking Number:
11SB2-0126
Solicitation Year:
2011
Solicitation Topic Code:
SB112-005
Solicitation Number:
2011.2
Small Business Information
Spectrasilk, Inc.
196 Boston Avenue, Suite 1700, Medford, MA, -
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
829358964
Principal Investigator
 Eun Gil
 Scientist
 (339) 221-3038
 eunseokgil@gmail.com
Business Contact
 Keleigh Sanford
Title: President&CEO
Phone: (339) 221-3038
Email: spectrasilk@gmail.com
Research Institution
 Stub
Abstract
The need for improved biological sample collection and processing for diagnostic applications has grown with the advent of new assays based on small sample sizes and high performance analytics. In contrast to the advances in these analytics, the ability to collect, stabilize, ship and utilize such samples has lagged in terms of development. We offer a relatively simple platform based on recent discoveries of the unique features of silk proteins as remarkably robust stabilization matrices for biological samples. Preliminary data demonstrates remarkable collection and stabilization of labile substrates, such as enzymes, antibodies, vaccines and hemoglobin in the silk matrix, with retention of function over months. This feature derives from the unique protein block copolymer structure of silk, dominated by hydrophobicity with small nanodomains for limited entrained water. This novelty extends well beyond the stabilization features, as the protein is relatively simple to utilize in an aqueous or lyophilized format, can be cast into any form or shape, provides stability of entrapped biologicals over months without refrigeration, can be formed into credit-card formats with optical or Electromagnetic (e.g. RF) features to permit interrogation of the activity of the contents, or can be deconstructed to remove the contents for analysis.

* information listed above is at the time of submission.

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