Multifunctional Stabilization Matrix for Biological Samples

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W31P4Q-12-C-0023
Agency Tracking Number: 11SB2-0126
Amount: $99,962.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2011
Solicitation Topic Code: SB112-005
Solicitation Number: 2011.2
Small Business Information
196 Boston Avenue, Suite 1700, Medford, MA, -
DUNS: 829358964
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Eun Gil
 (339) 221-3038
Business Contact
 Keleigh Sanford
Title: President&CEO
Phone: (339) 221-3038
Research Institution
The need for improved biological sample collection and processing for diagnostic applications has grown with the advent of new assays based on small sample sizes and high performance analytics. In contrast to the advances in these analytics, the ability to collect, stabilize, ship and utilize such samples has lagged in terms of development. We offer a relatively simple platform based on recent discoveries of the unique features of silk proteins as remarkably robust stabilization matrices for biological samples. Preliminary data demonstrates remarkable collection and stabilization of labile substrates, such as enzymes, antibodies, vaccines and hemoglobin in the silk matrix, with retention of function over months. This feature derives from the unique protein block copolymer structure of silk, dominated by hydrophobicity with small nanodomains for limited entrained water. This novelty extends well beyond the stabilization features, as the protein is relatively simple to utilize in an aqueous or lyophilized format, can be cast into any form or shape, provides stability of entrapped biologicals over months without refrigeration, can be formed into credit-card formats with optical or Electromagnetic (e.g. RF) features to permit interrogation of the activity of the contents, or can be deconstructed to remove the contents for analysis.

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government