Genetically Programmable Spherical Nucleic Acids as Rapidly Adaptable Nanotherapeutics

Award Information
Agency:
Department of Defense
Branch
Defense Advanced Research Projects Agency
Amount:
$149,295.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
W911QX-12-C-0073
Agency Tracking Number:
D121-003-0014
Solicitation Year:
2012
Solicitation Topic Code:
SB121-003
Solicitation Number:
2012.1
Small Business Information
AuraSense Therapeutics LLC
8045 Lamon Avenue, Skokie, IL, -
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
968721535
Principal Investigator:
David Giljohann
Chief Scientific Officer
(847) 467-2887
dgiljohann@aurasense.com
Business Contact:
Percy Crocker
VP of Commercial Development
(847) 467-2885
pcrocker@aurasense.com
Research Institution:
Stub




Abstract
AuraSense Therapeutics is developing oligonucleotide-modified gold nanoparticles called spherical nucleic acid (SNA) constructs, which are a powerful new way of regulating cellular gene expression. AuraSense Therapeutics will use SNAs as genetically programmable antimicrobial agents in a manner to provide a rapid and effective way to develop next generation antibiotics. The outcome of this work will be a new approach to generating bactericides- a rapidly adaptable genetically programmable nanoparticle therapeutic (RANT). The strategy is designed to be capable of being rapidly re-programmed to counter microbial threats, both natural and engineered. Importantly, our system can be adapted to kill emerging and mutating microbial threats, on-the-fly, by simply changing the oligonucleotide sequence conjugated to the Au NP surface. Because the constructs only change in genetic targeting sequence, it is a way in which to develop new agents without altering major toxicity and biodistribution profiles. As a result, an argument can be made for compassionate use of a new sequence via an abbreviated pharmaceutical development cycle.

* information listed above is at the time of submission.

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