PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles

Award Information
Agency:
Department of Defense
Branch
Defense Advanced Research Projects Agency
Amount:
$100,000.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
W911QX-12-C-0074
Award Id:
n/a
Agency Tracking Number:
D121-003-0051
Solicitation Year:
2012
Solicitation Topic Code:
SB121-003
Solicitation Number:
2012.1
Small Business Information
Agave BioSystems, Inc. (Currently AGAVE BIOSYSTEMS INC.)
P.O. Box 100, Ithaca, NY, -
Hubzone Owned:
Y
Minority Owned:
Y
Woman Owned:
N
Duns:
022552900
Principal Investigator:
Joel Tabb
Principal Scientist
(607) 272-0002
jtabb@agavebio.com
Business Contact:
Noe Salazar
President
(512) 656-6200
nsalazar@agavebio.com
Research Institution:
Stub




Abstract
Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for the identification of essential and drug resistance genes within the target pathogens. These genes will be used to develop and synthesize PNA based anti-sense oligonucleotides. These PNAs are designed to suppress the growth and destroy the target microorganisms. DNA nanoparticles coated with CPPs will be used to get the anti-sense PNAs into the target microorganisms. Combined, these components will allow for the rapid targeting of essential or drug resistance microbial genes, and the delivery of stable antisense oligonucleotides into the target microorganisms.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government