PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W911QX-12-C-0074
Agency Tracking Number: D121-003-0051
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: SB121-003
Solicitation Number: 2012.1
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100, Ithaca, NY, -
DUNS: 022552900
HUBZone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 Joel Tabb
 Principal Scientist
 (607) 272-0002
 jtabb@agavebio.com
Business Contact
 Noe Salazar
Title: President
Phone: (512) 656-6200
Email: nsalazar@agavebio.com
Research Institution
 Stub
Abstract
Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for the identification of essential and drug resistance genes within the target pathogens. These genes will be used to develop and synthesize PNA based anti-sense oligonucleotides. These PNAs are designed to suppress the growth and destroy the target microorganisms. DNA nanoparticles coated with CPPs will be used to get the anti-sense PNAs into the target microorganisms. Combined, these components will allow for the rapid targeting of essential or drug resistance microbial genes, and the delivery of stable antisense oligonucleotides into the target microorganisms.

* information listed above is at the time of submission.

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