Controlling Antibiotic Resistance by Vaccinating Bacterial Populations

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W31P4Q-13-C-0063
Agency Tracking Number: D122-001-0139
Amount: $150,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: SB122-001
Solicitation Number: 2012.2
Small Business Information
27 Drydock Ave, 8th Floor, Boston, MA, -
DUNS: 827811626
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Reshma Shetty
 Founder
 (877) 422-5362
 rshetty@ginkgobioworks.com
Business Contact
 First Last
Title: Founder
Phone: (814) 422-5362
Email: rshetty@ginkgobioworks.com
Research Institution
 Stub
Abstract
The prevalence of antibiotic resistant bacteria has risen dramatically over the past decades with over 70% of hospital bacterial infections harboring resistance to one or more classes of antibiotics. To date, the rise of drug resistant pathogens has been addressed by improved containment practices, judicious use of antibiotic treatments, and government-sponsored antibiotic research and development programs. Despite these measures, we are still facing a losing battle against the spread of antibiotic resistance. Given these significant challenges, both technical and economic, new strategies for combating antibiotic resistance are desperately needed. We propose a novel strategy that will limit the occurrence and spread of antibiotic resistance by targeting the genetic elements that encode antibiotic resistance, rather than any particular microbial species or strain. The approach is therefore broadly applicable to both Gram-positive and negative bacteria. To achieve this goal, we propose to use engineered mobile genetic elements to"vaccinate"microbial communities against uptake and dissemination of genetically-encoded antibiotic resistance elements. This approach is now made possible by technology advances in synthetic biology centered around gene and genome design and construction.

* Information listed above is at the time of submission. *

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