A Vacuum-Actuated Microneedle Patch with Integrated Reservoir (VAMPIRE) for Minimally Invasive Blood Sampling

Award Information
Agency:
Department of Defense
Branch
Defense Advanced Research Projects Agency
Amount:
$100,000.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
W31P4Q-13-C-0032
Agency Tracking Number:
D122-003-0054
Solicitation Year:
2012
Solicitation Topic Code:
SB122-003
Solicitation Number:
2012.2
Small Business Information
Lynntech, Inc.
2501 Earl Rudder Freeway South, College Station, TX, -
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
184758308
Principal Investigator:
Sriram Shankar
Sr. Scientist
(979) 764-2200
sriram.shankar@lynntech.com
Business Contact:
G. Hisaw
Sr. Contracts Administrator
(979) 764-2218
renee.hisaw@lynntech.com
Research Institution:
Stub




Abstract
Blood comprises a comprehensive compendium of biomolecules that is fully representative of human health; identification of specific biomarkers is useful for diagnosis, prediction, and monitoring of health, in real-time, making it the bio-fluid of choice for analytical applications. However, owing to the broad range of biomolecules in blood (10-log orders), the distribution of very low-level biomarkers in small volumes is governed by Poissonian principles and is not adequately representative. Thus, pinprick-based techniques often are not useful for accurate detection of such biomarkers. It is necessary to collect a larger, more representative volume of blood, but this is non-trivial, often requiring clinically-trained phlebotomists and highly invasive, painful methods. Lynntech is proposing the development of a low power/cost, minimally invasive, and relatively pain-free single-use device (VAMPIRE) for collecting larger blood samples (0.1-1 mL). The proposed device will be developed with a view towards potential future in-line integration with extant point-of-care diagnostics for easy, deployable use in remote settings. Additionally, the integrated reservoir will be designed to facilitate sample collection and storage for later-expanded clinical testing, if necessary. Sample collection is the weakest link in the chain of bioanalysis; VAMPIRE will provide unsurpassed, controlled, reproducible, blood-sample collection abilities that will bridge this niche.

* information listed above is at the time of submission.

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