Development of a Multiplexed Antigen Screening Platform for Detecting Evidence of Mycobacterium Tuberculosis Infections

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$149,997.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
FA8650-12-M-6254
Award Id:
n/a
Agency Tracking Number:
O112-H05-3044
Solicitation Year:
2011
Solicitation Topic Code:
OSD11-H05
Solicitation Number:
2011.2
Small Business Information
8100 Shaffer Parkway, Suite #130, Littleton, CO, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
148034408
Principal Investigator:
Jian Zhang
Research Scientist
(303) 792-5615
jianz@adatech.com
Business Contact:
Clifton Brown, Jr.
President&CEO
(303) 792-5615
cliffb@adatech.com
Research Institution:
Stub




Abstract
Tuberculosis (TB) is a re-emerging infectious disease threat worldwide. To protect the health of US military personnel, TB screen is required for military personnel at the time of service entrance. However, current TB screening methods TST and IGRA used in military population have their drawbacks in application such as high false positives and being heavily lab dependent. Here ADA Technologies, Inc. (ADA) proposes multiplexed M. tuberculosis (Mtb) antibody screen method based on a sensitive 3-D biomimetic microarray system. In Phase I effort, preliminary feasibility assessment will be performed based on the selection of multiple Mtb-specific antigens that can form composite biomarkers via statistical analysis to achieve optimal detection sensitivity and specificity. The Phase I results would provide justification and guidance for a continued development effort in Phase II, which will create a high-throughput (HTS) and miniaturized platform for TB screen in military populations.

* information listed above is at the time of submission.

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