Development of a Multiplexed Antigen Screening Platform for Detecting Evidence of Mycobacterium Tuberculosis Infections

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: FA8650-12-M-6254
Agency Tracking Number: O112-H05-3044
Amount: $149,997.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2011
Solicitation Topic Code: OSD11-H05
Solicitation Number: 2011.2
Small Business Information
8100 Shaffer Parkway, Suite #130, Littleton, CO, -
DUNS: 148034408
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Jian Zhang
 Research Scientist
 (303) 792-5615
 jianz@adatech.com
Business Contact
 Clifton Brown, Jr.
Title: President&CEO
Phone: (303) 792-5615
Email: cliffb@adatech.com
Research Institution
 Stub
Abstract
Tuberculosis (TB) is a re-emerging infectious disease threat worldwide. To protect the health of US military personnel, TB screen is required for military personnel at the time of service entrance. However, current TB screening methods TST and IGRA used in military population have their drawbacks in application such as high false positives and being heavily lab dependent. Here ADA Technologies, Inc. (ADA) proposes multiplexed M. tuberculosis (Mtb) antibody screen method based on a sensitive 3-D biomimetic microarray system. In Phase I effort, preliminary feasibility assessment will be performed based on the selection of multiple Mtb-specific antigens that can form composite biomarkers via statistical analysis to achieve optimal detection sensitivity and specificity. The Phase I results would provide justification and guidance for a continued development effort in Phase II, which will create a high-throughput (HTS) and miniaturized platform for TB screen in military populations.

* Information listed above is at the time of submission. *

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