Development of an Alternative Screening Method for Detecting Evidence of Mycobacterium Tuberculosis Infections

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$150,000.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
FA8650-12-M-6251
Award Id:
n/a
Agency Tracking Number:
O112-H05-3154
Solicitation Year:
2011
Solicitation Topic Code:
OSD11-H05
Solicitation Number:
2011.2
Small Business Information
3750 W. Main Street; Suite # 230, Norman, OK, 73072
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
614520026
Principal Investigator:
Bijo Mathew
President
(405) 406-3294
bpmathew@bijhem.com
Business Contact:
Hema Mathew
Vice-President
(405) 820-6852
hema_mathew@hotmail.com
Research Institution:
Stub




Abstract
This Small Business Innovation research Phase I proposes the development of a practical and reliable in-vitro test for detecting the evidence of Mycobacterium tuberculosis (MTB) infection as an alternative to the tuberculin skin test (PPD-TST) and to the interferon gamma release assays (IGRAs). The proposed methodology will be a powerful detection technology in clinical diagnosis owing to its detection sensitivity. Tuberculosis is caused by Mycobacterium tuberculosis bacterium. Tuberculosis (TB) remains to be one of the major causes of death from a single infectious agent worldwide. An estimated 2 billion people are infected all over the world with this disease. According to WHO global tuberculosis control report 2010, there were ~ 9.4 million reported new cases and 1.7 million people lost their lives from TB in 2009. Because of the increase in Multidrug-resistance (MDR) problems, there is an increased concern in the spread of Tuberculosis worldwide. Here, for the first time we are utilizing a synthetic biology based variant PCR technique to develop next generation MTB detection tools

* information listed above is at the time of submission.

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