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Development of an Alternative Screening Method for Detecting Evidence of Mycobacterium Tuberculosis Infections

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: FA8650-12-M-6255
Agency Tracking Number: O112-H05-3205
Amount: $150,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: OSD11-H05
Solicitation Number: 2011.2
Solicitation Year: 2011
Award Year: 2012
Award Start Date (Proposal Award Date): 2011-12-15
Award End Date (Contract End Date): N/A
Small Business Information
2585 Nina Street
Pasadena, CA -
United States
DUNS: 011114167
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: Yes
Principal Investigator
 Hiep-Hoa Nguyen
 (714) 791-1774
Business Contact
 Hiep-Hoa Nguyen
Title: President
Phone: (714) 791-1774
Research Institution

The objective of this proposal is to develop an alternative to the tuberculin test and interferron-gamma release assays for the diagnosis of active and latent tuberculosis. Toward this end, a rapid test based on the detection of blood antibodies specific to Mycobacteria tuberculosis antigens will be devised for the serodiagnosis of active and latent TB. Selected and highly immunogenic antigens encoded in regions of difference in the genome of M. tuberculosis will be prepared. The recombinant antigens will be evaluated for possible usage in such a test by screening them with TB serum collections through ELISAs. The recombinant antigens subsequently will be used to create prototypes for further evaluation during Phase II and III.

* Information listed above is at the time of submission. *

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