Noninvasive 3-D optical quantitative imaging of engineered tissue

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: W81XWH-12-C-0081
Agency Tracking Number: O112-H08-3165
Amount: $149,991.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2011
Solicitation Topic Code: OSD11-H08
Solicitation Number: 2011.2
Small Business Information
Diagnostic Photonics
200 South Wacker, Suite 3100, Chicago, IL, -
DUNS: 829708903
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Andrew Citadine
 President and CEO
 (312) 320-5478
Business Contact
 Andrew Cittadine
Title: President and CEO
Phone: (312) 320-5478
Research Institution
This project will bring interferometric synthetic aperture microscopy (ISAM), a powerful new method of computed microscopy, to bear on the problem of quantitative tissue assessment. The promise of tissue engineering, including wound healing, is limited unless the tissue is treated correctly at optimal times during growth. Therefore, continuous, nondestructive, microscopic 3-D visualization and quantification is critical. Diagnostic Photonics is developing a system for surgical guidance and assessment of tumors using ISAM. There is a synergistic opportunity to apply ISAM to assess tissue in vitro. This project will demonstrate ISAM for 3-D visualization and non-destructive assessment of tissue. Commercially-procured tissue will be imaged using DxP"s prototype demonstrating the use of ISAM to quantitatively assess resolution and depth of penetration. Designs for integration of the probe with a bioreactor will be produced. This will allow rapid progress early in Phase II to introduce ISAM into an engineered tissue lab. A demonstration of the instrument will be provided for DoD assessment. In Phase II, ISAM will be applied in vitro to the imaging of engineered tissue in a laboratory where time evolution of growing tissues will be investigated by producing 4-D images. The microscope probe will be added to a working bioreactor.

* information listed above is at the time of submission.

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