Bioactive Superporous Hydrogels with Vascular Channels for Muscle Tissue Engineering

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: W81XWH-12-C-0053
Agency Tracking Number: O112-H12-3096
Amount: $150,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2011
Solicitation Topic Code: OSD11-H12
Solicitation Number: 2011.2
Small Business Information
Luna Innovations Incorporated
1 Riverside Circle, Suite 400, Roanoke, VA, -
DUNS: 627132913
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Christopher Tison
 Principal Investigator
 (434) 220-2518
 tisonc@lunainnovations.com
Business Contact
 Maggie Hudson
Title: Senior Contracts Administrator
Phone: (434) 483-4254
Email: submissions305@lunainnovations.com
Research Institution
 Stub
Abstract
There is a substantial clinical need in both civilian and battlefield injuries for the repair and regeneration of large-volume-loss skeletal muscle tissue injuries. Current standards of care rely on rotational tissue grafts and often result in substantial morbidity, pain, and disfigurement. Luna Innovations Incorporated proposes the development of a hierarchically organized, superporous hydrogel construct with aligned vascular channels. The construct formation will utilize a novel sacrificial template for micropore formation in addition to photomasking for vascular channel formation. The scaffolds will be functionalized with a bioactive glycosaminoglycan capable of recruiting and binding important growth factors, extracellular matrix proteins, and progenitor cells. This functionalization will serve to both promote angiogenesis within the construct channels and induce skeletal muscle regeneration by supporting endogenous progenitor cells. Hydrolytically degradable linkages will be introduced through a copolymer addition and degradation rates will be controlled by the addititive ratio. The developed construct will be biodegradable, biocompatible, hierarchically organized and provide both structural and chemical cues for angiogenesis and skeletal muscle tissue regeneration.

* information listed above is at the time of submission.

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