Cell Regulation with Polyvalent Nanoparticles

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: FA8650-12-C-6308
Agency Tracking Number: F103-043-2330
Amount: $728,581.00
Phase: Phase II
Program: SBIR
Awards Year: 2012
Solicitation Year: 2010
Solicitation Topic Code: AF103-043
Solicitation Number: 2010.3
Small Business Information
AuraSense, LLC
1801 Maple Avenue, Suite 4301, Evanston, IL, -
DUNS: 831421958
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 David Giljohann
 Chief Scientific Officer
 (847) 467-2887
Business Contact
 Percy Crocker
Title: VP of Commercial Developm
Phone: (847) 467-2885
Email: pcrocker@aurasense.com
Research Institution
ABSTRACT: AuraSense is developing and commercializing NanoFlare technology as an enabling tool for detecting RNA levels in cells. Current methods for sensing of viral exposure require great amounts of virus particles to be present in blood, or extensive processing of blood to isolate virus-specific genomic markers. We will develop NanoFlare sensors that can penetrate through skin, enter the bloodstream and detect viral targets. Once inside blood cells, the sensors will signal the presence of virus-specific genomic markers. This signal can be detected by fluorescence spectroscopy. The flexibility of the NanoFlare platform will facilitate the tailoring of the NanoFlare to meet current and emerging threats. BENEFIT: AuraSense will demonstrate an approach for detection of viral RNA in living cells. This will be accomplished using non-invasive systemic delivery through the skin. NanoFlare technology could thus be adapted for field deployment, for example by creating a patch to systemically deliver NanoFlares. We envision that a NanoFlare patch could be used by the warfighter to determine viral infection by taking a finger prick blood sample, with a rapid readout using a simple fluorescence detector such as a UV light source. In the commercial space, such a point-of-care fluorescence detection can be used by doctors in the clinic for rapid PCR-free diagnostic assays.

* information listed above is at the time of submission.

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