Topical Nitric Oxide for the Treatment of Acute Military Wound Infections

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$779,640.00
Award Year:
2012
Program:
SBIR
Phase:
Phase II
Contract:
W81XWH-11-C-0029
Award Id:
n/a
Agency Tracking Number:
A2-4831
Solicitation Year:
2010
Solicitation Topic Code:
A10-160
Solicitation Number:
2010.3
Small Business Information
4222 Emperor Blvd, Suite 470, Durham, NC, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
621609556
Principal Investigator:
Nathan Stasko
President
(919) 485-8080
nstasko@novantherapeutics.com
Business Contact:
Cari Green
Business Manager
(919) 354-2976
cgreen@novantherapeutics.com
Research Institution:
Stub




Abstract
Under battlefield conditions, warfighters face a wide range of cutaneous injuries, many of which are susceptible to life- and limb-threatening infections caused by multi-drug resistant bacteria. Nitric oxide is a powerful, broad spectrum antimicrobial agent that is naturally produced by the immune system. Nitric oxide"s ability to attack multiple cellular targets limits the chance for bacteria to develop resistance to it. The use of nitric oxide to treat infections has been hindered by the challenges associated with chemically storing the gas into a solid state and controlling its release. Novan"s nitric oxide-releasing silica technology, Nitricil, overcomes the past issues with nitric oxide-based therapeutics because it effectively stores large quantities of nitric oxide gas and allows the release to be"tuned"for use in acute trauma scenarios or longer term wound care applications. The technical innovation and flexibility of Nitricil clearly separates it from all other nitric oxide storage scaffolds. The goal of this Phase II research is to create the optimal topical nitric oxide releasing formulation to reduce burn wound infections and ultimately lead to a series of topical wound care products for the treatment of acute military infections.

* information listed above is at the time of submission.

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