Universal Bio-Sample Preparation Module

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911NF-12-C-0047
Agency Tracking Number: C2-0355
Amount: $726,668.00
Phase: Phase II
Program: SBIR
Awards Year: 2012
Solicitation Year: 2010
Solicitation Topic Code: A10-074
Solicitation Number: 2010.2
Small Business Information
Photonic Systems Division, 1845 W. 205th Street, Torrance, CA, -
DUNS: 153865951
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Gregory Zeltser
 Principal Scientist
 (310) 320-3088
 psproposals@poc.com
Business Contact
 Gordon Drew
Title: Chief Financial Officer
Phone: (310) 320-3088
Email: gedrew@poc.com
Research Institution
N/A
Abstract
Due to increasing recognition of sample preparation as the biggest challenge for biodefense and biomedical detection applications, CBD is seeking a platform technology for automated, universal sample preparation for biosensor systems using small volumes of samples in complex matrices. To address this need, Physical Optics Corporation (POC) proposes to develop a Universal Bio-sample Preparation (UniBioPrep) technology based on the combination of size-exclusion cleansing and dielectrophoretic continuous-flow bio-agent separation technique followed by bio-agent elution and collection. The innovations in the UniBioPrep module will enable the module to perform rapid and automated biological target separation from low volumes of various complex matrices, desalting if needed, concentration, and collection, without the use of labeling or specific reagents. In Phase I, POC demonstrated the feasibility of the UniBioPrep module by developing a benchtop prototype capable of separating and collecting individual classes of biological targets in buffer in<15 minutes. In Phase II, POC will further develop, refine, and validate the UniBioPrep into a module capable of separating the biological targets from complex matrices such as homogenized food, soil, or aqueous samples from an aerosol collector with high yield and purity. At the end of Phase II, the prototype will be at TRL-5 and MRL-4.

* Information listed above is at the time of submission. *

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