DEVELOPMENT OF A BIOSENSOR NANOFLUIDIC PLATFORM FOR INTEGRATION WITH TERAHERTZ SPECTROSCOPIC SYSTEM

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$749,959.00
Award Year:
2012
Program:
SBIR
Phase:
Phase II
Contract:
W911NF-12-C-0046
Award Id:
n/a
Agency Tracking Number:
C2-0358
Solicitation Year:
2010
Solicitation Topic Code:
CBD10-110
Solicitation Number:
2010.1
Small Business Information
104 Chaucer Rd., Charlottesville, VA 22901, Charlottesville, VA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
789962656
Principal Investigator:
TATIANA GLOBUS
PRINCIPLE INVESTIGATOR
(434) 296-2400
globus@vibratess.com
Business Contact:
TATIANA GLOBUS
PRESIDENT
(434) 926-2400
globus@vibratess.com
Research Institution:
Stub




Abstract
The goal of this project is demonstration of a nanofluidic sensor platform effective for label-free"THz-frequency spectroscopic fingerprinting"of biological molecules for detection, identification, and classification applications. In the Phase I project, the work involved a conceptual design of the proposed nanofluidic sensor package and development of technology for enclosing and wetting of the channels. The microchip was demonstrated to be appropriate for acquisition of THz-frequency spectroscopic features from bio-molecules (e.g., DNA, RNA, proteins) in solution and solid forms. Spectroscopic characterization of biological species inside nanofluidic channels with high sensitivity and high spectral and spatial resolution was demonstrated. In Phase II, a completely functioning nanofluidic sensor platform will be developed, tested, and refined in combination with a THz spectroscopic system. The focus of Phase II will be further developments on the inexpensive nanofluidic technology toward future commercialization and fabrication of an associated interface device to provide a packaged platform, readily interfaced with THz spectroscopy instruments, including commercially available systems. The efforts will aim for stand-alone operation with sample injection and fluidic control built into the platform to facilitate transparent operation by the user.

* information listed above is at the time of submission.

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