DEVELOPMENT OF A BIOSENSOR NANOFLUIDIC PLATFORM FOR INTEGRATION WITH TERAHERTZ SPECTROSCOPIC SYSTEM

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911NF-12-C-0046
Agency Tracking Number: C2-0358
Amount: $749,959.00
Phase: Phase II
Program: SBIR
Awards Year: 2012
Solitcitation Year: 2010
Solitcitation Topic Code: CBD10-110
Solitcitation Number: 2010.1
Small Business Information
VIBRATESS
104 Chaucer Rd., Charlottesville, VA 22901, Charlottesville, VA, -
Duns: 789962656
Hubzone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 TATIANA GLOBUS
 PRINCIPLE INVESTIGATOR
 (434) 296-2400
 globus@vibratess.com
Business Contact
 TATIANA GLOBUS
Title: PRESIDENT
Phone: (434) 926-2400
Email: globus@vibratess.com
Research Institution
 Stub
Abstract
The goal of this project is demonstration of a nanofluidic sensor platform effective for label-free"THz-frequency spectroscopic fingerprinting"of biological molecules for detection, identification, and classification applications. In the Phase I project, the work involved a conceptual design of the proposed nanofluidic sensor package and development of technology for enclosing and wetting of the channels. The microchip was demonstrated to be appropriate for acquisition of THz-frequency spectroscopic features from bio-molecules (e.g., DNA, RNA, proteins) in solution and solid forms. Spectroscopic characterization of biological species inside nanofluidic channels with high sensitivity and high spectral and spatial resolution was demonstrated. In Phase II, a completely functioning nanofluidic sensor platform will be developed, tested, and refined in combination with a THz spectroscopic system. The focus of Phase II will be further developments on the inexpensive nanofluidic technology toward future commercialization and fabrication of an associated interface device to provide a packaged platform, readily interfaced with THz spectroscopy instruments, including commercially available systems. The efforts will aim for stand-alone operation with sample injection and fluidic control built into the platform to facilitate transparent operation by the user.

* information listed above is at the time of submission.

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