Point of Injury Sampling Technology for Battlefield Molecular Diagnostics

Award Information
Agency:
Department of Defense
Branch
Defense Advanced Research Projects Agency
Amount:
$1,375,238.00
Award Year:
2012
Program:
SBIR
Phase:
Phase II
Contract:
W31P4Q-12-C-0095
Award Id:
n/a
Agency Tracking Number:
D2-1135
Solicitation Year:
2011
Solicitation Topic Code:
SB111-001
Solicitation Number:
2011.1
Small Business Information
3711 Market Street, Suite 970, Philadelphia, PA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
963268151
Principal Investigator:
RobertHart
Principal Scientist
(215) 966-6251
hart@optofluidicscorp.com
Business Contact:
DavidErickson
President and CEO
(215) 966-6251
erickson@optofluidicscorp.com
Research Institute:
Stub




Abstract
In this project Optofluidics, Inc. proposes to develop the Molecular Medic a point-of-care device for sample collection, processing, and quantification of blood-borne biomarkers. The technology is based on (1) a finger prick assay, (2) a capillary-driven blood filtration system, (3) a novel"nanofluidic collapse"protein concentration technique and (4) a mutliplexable, reconfigurable, ultrasensitive Nanoscale Optofluidic Sensor Array. Key to the envisioned success of the Molecular Medic, is the combination of the most sensitive mass sensor (to our knowledge) with a novel concentration technique that, together will allow a point-of-care device to have comparable performance to a benchtop clinical test. The Molecular Medic builds on the success of the sample processing system that is currently nearing development completion in Phase I. Our initial focus is on diagnosing traumatic brain injury using a marker panel developed by our collaborators at Banyan Biomarkers. With nearly 2 million cases of TBI per year (globally) we expect to have a major impact beyond the military"s interest. With our devices untrained personnel, first responders or clinicians without convenient access to a clinical lab could diagnose with great certainty the presence of injuries and diseases and make more streamlined and informed decisions regarding treatment.

* information listed above is at the time of submission.

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