Antimicrobial Drug Targeted to Essential Bacterial Genes in Wound Infection Pathogens

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$100,000.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-12-C-0003
Agency Tracking Number:
A112-104-0894
Solicitation Year:
2011
Solicitation Topic Code:
A11-104
Solicitation Number:
2011.2
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100, Ithaca, NY, -
Hubzone Owned:
Y
Socially and Economically Disadvantaged:
Y
Woman Owned:
N
Duns:
022552900
Principal Investigator:
Mehran Pazirandeh
Staff Scientist
(607) 272-0002
mehranp@agavebio.com
Business Contact:
Noe Salazar
President
(512) 656-6200
nsalazar@agavebio.com
Research Institution:
Stub




Abstract
Wounds infected with drug-resistant Gram-negative bacteria can increase morbidity, hospital length of stay and cost. Among these Klebsiella pneumoniae and Pseudomonas aeruginosa have become important causes of concern in military personnel wounded in battlefield. New classes of antimicrobial agents are needed to combat this threat. Emerging work has focused on a new type of strategy through gene silencing by antisense mechanisms to block intracellular synthesis of housekeeping proteins via inhibition of mRNA. Among the various antisense molecules Peptide Nucleic Acids (PNAs) have several advantages and are ideally suited for development as antibacterial agents. PNAs are resistant to nucleases, proteases, and degradative enzymes, have a high binding affinity and a long half-life compared inside the cells compared to antibiotics. Therefore, in this Phase I Agave BioSystems proposes to develop antisense PNA molecules to block synthesis of housekeeping proteins in K. pneumoniae

* information listed above is at the time of submission.

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