Blood Purification for Organ Failure

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-12-C-0034
Agency Tracking Number: A112-105-0691
Amount: $99,974.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solitcitation Year: 2011
Solitcitation Topic Code: A11-105
Solitcitation Number: 2011.2
Small Business Information
Sentien Biotechnologies, Inc.
196 Boston Ave, Suite 2200, Medford, MA, -
Duns: 828970900
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Arno Tilles
 Chief Technology Officer
 (781) 361-9031
Business Contact
 Brian Miller
Title: President
Phone: (781) 361-9031
Research Institution
Sentien Biotechnologies is developing cellular devices for the treatment of acute organ failure, including polytrauma-induced multiple organ dysfunction syndrome (MODS). Our flagship product, the Sentinel, is a dialyzer with mesenchymal stem cells (MSCs) seeded in the extracapillary space, designed to connect to the bloodstream of patients and provide anti-inflammatory, cytoprotective and regenerative support via secreted factors from the MSCs. We propose here, in this Phase I and Phase I Option plan, to begin testing of the Sentinel in a polytrauma model in swine. For the Phase I period, we propose to work in conjunction with several key consultants to compose an IACUC-approved protocol for administration of our therapy to swine subjected to polytrauma and shock. This protocol will be based on a previously developed model of polytrauma that was devised by our collaborators, and it is with their help that we also plan to analyze the cytokine and myoglobin profile of banked samples from their previous work during the Phase I Option period. By accomplishing these two important tasks, we anticipate being well poised to evaluate the applicability of the porcine model, and assess our device treatment for polytrauma in swine during follow-on Phases of SBIR support.

* information listed above is at the time of submission.

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