Quadruple-Action Hydrogel Microbeads for Primary Management of Burn Wounds

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$100,000.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-12-C-0005
Agency Tracking Number:
A112-108-0043
Solicitation Year:
2011
Solicitation Topic Code:
A11-108
Solicitation Number:
2011.2
Small Business Information
Lynntech, Inc.
7610 Eastmark Drive, College Station, TX, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
184758308
Principal Investigator:
Sanjiv Lalwani
Scientist
(979) 764-2200
sanjiv.lalwani@lynntech.com
Business Contact:
G. Hisaw
Contracts Administrator
(979) 764-2218
renee.hisaw@lynntech.com
Research Institution:
Stub




Abstract
Exogenous topical NO has been demonstrated as a broad-spectrum antimicrobial agent (Ghaffari, 2006), and is capable of providing numerous wound healing benefits if delivered at the proper concentrations (Shekhter, 2005). Practical deployment of NO however is missing due to the lack of products that stably sequester and controllably deliver NO at therapeutically relevant levels, especially upon application of an external trigger. This proposal seeks to develop a stable molecular NO storage and delivery modality using micropowder hydrogel bead technology to transition to the battlefield and/or supporting treatment centers. Specifically, the synthesis of a polymeric NO solid-state material using an inexpensive and biocompatible polymer is proposed. This solid-state NO depot will have a water-triggered NO release ability. The envisioned end-product has quadruple activity: it delivers a large bolus of NO for instant wound disinfection; it forms a semi-permeable barrier that prevents new colonizing pathogens access to the wound; it exhibits partial hemostatic activity, and; it promotes wound healing due to sustained release of low levels of NO while allowing oxygen to enter the wound bed and moisture vapor to exit. Use of this material will be convenient and will allow point-of-injury care, simply requiring a mere rip-and-apply or rip-mix-with-water-and-apply administration protocol.

* information listed above is at the time of submission.

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