Nano-Therapeutics for Secondary Lymphedema

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$99,977.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-12-C-0098
Award Id:
n/a
Agency Tracking Number:
A113-122-0047
Solicitation Year:
2011
Solicitation Topic Code:
A11-122
Solicitation Number:
2011.3
Small Business Information
Photonic Systems Division, 20600 Gramercy Place, Bldg. 100, Torrance, CA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
153865951
Principal Investigator:
GregoryZeltser
Principal Scientist
(310) 320-3088
psproposals@poc.com
Business Contact:
GordonDrew
Chief Financial Officer
(310) 320-3088
gedrew@poc.com
Research Institute:
n/a
Abstract
To address the U.S. Army need for a curative treatment for secondary lymphedema that will restore the function of the lymphatic vessel system by stimulating lymphangiogenesis, Physical Optics Corporation (POC) proposes to develop a Nano-Therapeutics for Secondary Lymphedema (NATSEL). The NATSEL will include a nanocarrier (NC) loaded with VEGF-C and ANG-2, a biocompatible gel to contain the NC and a microneedle patch for transdermal delivery of the therapeutic. The innovations in NATSEL will enable minimally invasive targeted delivery of the VEGF-C and ANG-2 to the lymphatic endothelial cells. The NATSEL modality has minimal toxicity and immunogenicity profiles and is easy to administer. In Phase I, POC will demonstrate the feasibility of the NATSEL concept by developing a prototype that can stimulate lymphangiogenesis in appropriate cell culture, resulting in lymphatic endothelial cell proliferation, migration, and tube formation and branching. In Phase II, POC plans to demonstrate, optimize, and validate the NATSEL therapeutic strategy in animal models of secondary lymphedema. The FDA approval pathway will be outlined and considered at each developmental stage.

* information listed above is at the time of submission.

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