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Nano-Therapeutics for Secondary Lymphedema

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-12-C-0098
Agency Tracking Number: A113-122-0047
Amount: $99,977.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: A11-122
Solicitation Number: 2011.3
Timeline
Solicitation Year: 2011
Award Year: 2012
Award Start Date (Proposal Award Date): 2012-01-23
Award End Date (Contract End Date): N/A
Small Business Information
Photonic Systems Division 20600 Gramercy Place, Bldg. 100
Torrance, CA -
United States
DUNS: 153865951
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 Gregory Zeltser
 Principal Scientist
 (310) 320-3088
 psproposals@poc.com
Business Contact
 Gordon Drew
Title: Chief Financial Officer
Phone: (310) 320-3088
Email: gedrew@poc.com
Research Institution
N/A
Abstract

To address the U.S. Army need for a curative treatment for secondary lymphedema that will restore the function of the lymphatic vessel system by stimulating lymphangiogenesis, Physical Optics Corporation (POC) proposes to develop a Nano-Therapeutics for Secondary Lymphedema (NATSEL). The NATSEL will include a nanocarrier (NC) loaded with VEGF-C and ANG-2, a biocompatible gel to contain the NC and a microneedle patch for transdermal delivery of the therapeutic. The innovations in NATSEL will enable minimally invasive targeted delivery of the VEGF-C and ANG-2 to the lymphatic endothelial cells. The NATSEL modality has minimal toxicity and immunogenicity profiles and is easy to administer. In Phase I, POC will demonstrate the feasibility of the NATSEL concept by developing a prototype that can stimulate lymphangiogenesis in appropriate cell culture, resulting in lymphatic endothelial cell proliferation, migration, and tube formation and branching. In Phase II, POC plans to demonstrate, optimize, and validate the NATSEL therapeutic strategy in animal models of secondary lymphedema. The FDA approval pathway will be outlined and considered at each developmental stage.

* Information listed above is at the time of submission. *

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