Provide Human Reticulocytes for in vitro Culturing of Malaria Parasites

Award Information
Agency:
Department of Defense
Amount:
$99,984.00
Program:
SBIR
Contract:
W81XWH-12-C-0100
Solitcitation Year:
2011
Solicitation Number:
2011.3
Branch:
Army
Award Year:
2012
Phase:
Phase I
Agency Tracking Number:
A113-124-0370
Solicitation Topic Code:
A11-124
Small Business Information
ChromoLogic LLC
180 N Vinedo Ave, Pasadena, CA, -
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
168312028
Principal Investigator
 Julian Down
 Director of Biologics
 (626) 381-9974
 jaxtelle@chromologic.com
Business Contact
 Naresh Menon
Title: CEO
Phone: (626) 381-9974
Email: nmenon@chromologic.com
Research Institution
 Stub
Abstract
The parasite Plasmodium vivax, transmitted by the Anopheles mosquito, is the second major cause of malaria worldwide and the major cause of malaria outside Africa. The infection is characterized by a chronic course of malaria with acute episodes of relapse after months to years of asymptomatic dormancy. Research focusing on P. vivax has been hindered by lack of a practical continuous culture system as the parasite preferentially invades young erythrocytes (reticulocytes), which are difficult to obtain routinely and in high enough numbers. To address this critical need, ChromoLogic, LLC, (CL) proposes to leverage the expertise of its biologists in this area by developing a genetically modified human cell line to acquire essential features that serve as artificial reticulocytes (Art-Ret) so as to provide the Army a consistent, reliable and sufficient number of surrogate cells that are capable of being invaded by the P. vivax malaria and ensure long term culturing of the parasite.

* information listed above is at the time of submission.

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