Provide Human Reticulocytes for in vitro Culturing of Malaria Parasites

Award Information
Agency:
Department of Defense
Branch
n/a
Amount:
$99,984.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-12-C-0100
Award Id:
n/a
Agency Tracking Number:
A113-124-0370
Solicitation Year:
2011
Solicitation Topic Code:
A11-124
Solicitation Number:
2011.3
Small Business Information
180 N Vinedo Ave, Pasadena, CA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
168312028
Principal Investigator:
Julian Down
Director of Biologics
(626) 381-9974
jaxtelle@chromologic.com
Business Contact:
Naresh Menon
CEO
(626) 381-9974
nmenon@chromologic.com
Research Institution:
Stub




Abstract
The parasite Plasmodium vivax, transmitted by the Anopheles mosquito, is the second major cause of malaria worldwide and the major cause of malaria outside Africa. The infection is characterized by a chronic course of malaria with acute episodes of relapse after months to years of asymptomatic dormancy. Research focusing on P. vivax has been hindered by lack of a practical continuous culture system as the parasite preferentially invades young erythrocytes (reticulocytes), which are difficult to obtain routinely and in high enough numbers. To address this critical need, ChromoLogic, LLC, (CL) proposes to leverage the expertise of its biologists in this area by developing a genetically modified human cell line to acquire essential features that serve as artificial reticulocytes (Art-Ret) so as to provide the Army a consistent, reliable and sufficient number of surrogate cells that are capable of being invaded by the P. vivax malaria and ensure long term culturing of the parasite.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government