Provide Human Reticulocytes for in vitro Culturing of Malaria Parasites

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$99,984.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-12-C-0100
Agency Tracking Number:
A113-124-0370
Solicitation Year:
2011
Solicitation Topic Code:
A11-124
Solicitation Number:
2011.3
Small Business Information
ChromoLogic LLC
180 N Vinedo Ave, Pasadena, CA, -
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
168312028
Principal Investigator:
Julian Down
Director of Biologics
(626) 381-9974
jaxtelle@chromologic.com
Business Contact:
Naresh Menon
CEO
(626) 381-9974
nmenon@chromologic.com
Research Institution:
Stub




Abstract
The parasite Plasmodium vivax, transmitted by the Anopheles mosquito, is the second major cause of malaria worldwide and the major cause of malaria outside Africa. The infection is characterized by a chronic course of malaria with acute episodes of relapse after months to years of asymptomatic dormancy. Research focusing on P. vivax has been hindered by lack of a practical continuous culture system as the parasite preferentially invades young erythrocytes (reticulocytes), which are difficult to obtain routinely and in high enough numbers. To address this critical need, ChromoLogic, LLC, (CL) proposes to leverage the expertise of its biologists in this area by developing a genetically modified human cell line to acquire essential features that serve as artificial reticulocytes (Art-Ret) so as to provide the Army a consistent, reliable and sufficient number of surrogate cells that are capable of being invaded by the P. vivax malaria and ensure long term culturing of the parasite.

* information listed above is at the time of submission.

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