First Generation of Controlled-Release Bacteriocins/Anti-Microbials

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911QY-12-P-0099
Agency Tracking Number: A113-127-0084
Amount: $149,216.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2011
Solicitation Topic Code: A11-127
Solicitation Number: 2011.3
Small Business Information
Orbis Biosciences
2002 West 39th Avenue, Kansas City, KS, -
DUNS: 828536438
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 David Dumbauld
 Business Development Manager
 (913) 945-7796
Business Contact
 Maria Flynn
Title: Chief Executive Officer
Phone: (913) 945-6754
Research Institution
Combat ration Intermediate Moisture (IM) products use low pH and water content (aw) to discourage bacterial growth. The long-term goal of this proposal is to maintain the microbial stability of ration components over a two-year shelf life while increasing the pH and aw values for an improved organoleptic profile. The specific objective of this Phase I application is to develop microspheres for continuous, controlled-release of Nisaplin over a two-year period using Orbis"Precision Particle Fabrication (PPF) microsphere encapsulation technology. The incorporation of this time-released system in addition to a one-time injection during initial packaging would allow for higher pH and aw thresholds, providing a safe, high-quality ration platform with improved palatability. First, uniform, Nisaplin-loaded microspheres with three different diameters will be formulated to characterize in vitro release kinetics. Second, through in vitro release testing, the formulation of Nisaplin-loaded microspheres will be optimized to achieve sustained, two-year Nisaplin release. In the Phase I Option, the controlled-release system will be compared to single-dose delivery. The central hypothesis is that uniform, Nisaplin-loaded PPF microspheres will offer a cost- and dose-effective food preservation system with precisely tailored anti-microbial release characteristics to effectively inhibit gram-positive pathogens over the two year shelf-life of the food product.

* information listed above is at the time of submission.

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