Zwitterionic Clicking for Enhanced Orthopedics

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$186,625.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
1R43AR063551-01
Award Id:
n/a
Agency Tracking Number:
R43AR063551
Solicitation Year:
2012
Solicitation Topic Code:
NIAMS
Solicitation Number:
PA11-096
Small Business Information
1000 WESTGATE DR, STE 115, ST. PAUL, MN, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
148070860
Principal Investigator:
LAURIELAWIN
(651) 209-9757
llawin@isurtec.com
Business Contact:
PATRICKGUIRE
(651) 209-9757
pguire@isurtec.com
Research Institute:
Stub




Abstract
DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project is designed to develop new zwitterionic click methodology for orthopedic surfaces with enhanced durability. As Americans live longer and more actives lives, totaljoint replacement is becoming more common. Current orthopedic joints have average life spans of approximately 20 years. By that point wear on the joint causes particulate formation, with subsequent pain and inflammation, requiring eventual revision. Revision surgeries to replace joint implants are more difficult, painful, and expensive than initial joint replacement. Academic work from Japan demonstrated a promising photochemical graft coating of phosphorylcholine zwitterion that reduced wear significantlywhile also decreasing pro-inflammatory cytokine release and macrophage recruitment in vivo. However, this method uses hazardous monomer and will not scale well for manufacturing use. This project focuses on Click To coating methodology which consistsof a pre-made phosphorylcholine or other zwitterionic copolymer that will undergo very fast non-photochemical reactions with the functionalized ultrahigh crosslinked polyethylene orthopedic implant to achieve an implant with increased wear resistance. TheClick To technology will allow commercialization of the zwitterionic coating technology by a manufacturing-friendly process. PUBLIC HEALTH RELEVANCE: Zwitterionic coatings on orthopedic implants have tremendous potential for decreasing implant wear and improved anti-fouling properties. Approximately 600,000 Americans receive knee and hip implants annually in the US, over 1 million worldwide. This market is large, over 5.4 billion in 2006, and more than a fivefold increase in the number of total joint replacements are expected in the next 20 years. Substantial savings in the United States, on the order of more than 100 million, can be achieved with even a one year improvement of in the average life of an implant. The cost savings is a minor point when the benefit of an improved quality of life for the many users is considered by the elimination of the need for painful revision surgeries.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government