Develop Ponderomotive Phase Plate for Transmission Electron Microscopy of Biospec

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43GM098048-01A1
Agency Tracking Number: R43GM098048
Amount: $149,558.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: NIGMS
Solicitation Number: PA11-096
Small Business Information
455 BOLERO DR, DANVILLE, CA, 94526-5006
DUNS: 832780931
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (925) 683-6036
Business Contact
Phone: (925) 683-6036
Research Institution
DESCRIPTION (provided by applicant): Plans for the design, construction and demonstration of the world's first optically driven transmission electron microscope phase plate are described. This technology, known as a Ponderomotive Phase Plate, utilizes a focused laser to create a well defined phase shift of electrons passing through the back focal plane of the objective lens. This phase shift modulates the contrast transfer function of the instrument enabling high contrast images to be recorded at optimal focus while eliminating contrast reversals at lower spatial frequencies. This approach addresses and solves a multitude of issues associated with previous phase plate designs and is the only method proposed thus far that has the potential to deliver on the incredible biological imaging advantages that can be gained with a phase plate with none of the significant problems associated with Zernike and Boertsch phase plates. PUBLIC HEALTH RELEVANCE: IDES will provide an invaluable imaging tool for medical, pharmaceutical, and nano- technology researchers. The Pondermotive Phase Plate will enable the advancement of public health in areas as diverse as virology, drug discovery, drug delivery, cellular dynamics, and cell biology.

* Information listed above is at the time of submission. *

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