Phage Display Isolation of Antibodies against Antigenically Conserved Membrane Pr

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$214,214.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
1R43GM101718-01
Agency Tracking Number:
R43GM101718
Solicitation Year:
2012
Solicitation Topic Code:
NIGMS
Solicitation Number:
PA11-096
Small Business Information
INTEGRAL MOLECULAR
3711 MARKET ST, Suite 900, PHILADELPHIA, PA, -
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
34055645
Principal Investigator:
BENJAMIN DORANZ
(215) 966-6018
bdoranz@integralmolecular.com
Business Contact:
BENJAMIN DORANX
(215) 966-6061
bdoranz@integralmolecular.com
Research Institution:
Stub




Abstract
DESCRIPTION (provided by applicant): We propose to use a novel technology, the Lipoparticle, to capture and concentrate structurally intact membrane proteins in a format amenable to phage panning for MAb isolation. The use of Lipoparticles to pan phage display libraries represents a valuable approach for obtaining antibodies against conserved membrane protein antigens because 1) Lipoparticles contain high concentrations of conformationally-intact target receptors, 2) target receptors within Lipoparticles are not exposed to adjuvants or biologically destructive environments so remain structurally intact, and 3) target receptors with high sequence conservation across species can be used as targets. PUBLIC HEALTH RELEVANCE: This proposal will result in monoclonal antibodies against important membrane protein targets for therapeutic development, diagnostics, and biomedical research. Lipoparticles optimized as panning reagents will be developed as a commercial product, and Lipoparticle-derived MAbs against biomedically important membrane protein targets will be licensed for therapeutic development or diagnostic use, or enter the commercial market as research reagents.

* information listed above is at the time of submission.

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