A low-cost instrument for nucleic acid isolation.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$280,784.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
1R43GM103053-01
Award Id:
n/a
Agency Tracking Number:
R43GM103053
Solicitation Year:
2012
Solicitation Topic Code:
NIGMS
Solicitation Number:
PA11-096
Small Business Information
400 Sagner Avenue, Suite 300, FREDERICK, MD, 21701-6082
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
154704444
Principal Investigator:
CHRISTOPHERCOONEY
(301) 698-0101
cooney@akonni.com
Business Contact:
CHRISTOPHERCOONEY
(301) 698-0101
cooney@akonni.com
Research Institute:
Stub




Abstract
DESCRIPTION (provided by applicant): Sample preparation frequently presents a bottleneck for clinical molecular biology workflows. Whereas there are many readout detection modalities, there are only a handful of automated sample preparation workflow strategies. Existing instruments that are built around these sample preparation strategies and chemistries range in cost from 17- 150k, and yet they still do not include an integrated method of lysing difficult-to-disrupt organisms such as gram-positive bacteria or the acid fast bacilli (i.e., Mycobacterium). To address these limitations, we propose to integrate Akonni's sample preparation technologies into a low-cost automated instrument that can process a variety of sample types such as blood, nasopharyngeal swabs, and nasopharyngeal aspirate with a simple-to-use consumable kit. PUBLIC HEALTH RELEVANCE: Molecular diagnostics, which are tests that analyze the DNA and/or RNA in a sample, are becoming increasingly prevalent among clinical laboratory testmethods. An important, yet challenging, procedure, required of these tests, is to remove the DNA/RNA from the sample and wash away the impurities. We seek to develop a low-cost automated instrument to address this challenge

* information listed above is at the time of submission.

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