A low-cost instrument for nucleic acid isolation.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43GM103053-01
Agency Tracking Number: R43GM103053
Amount: $280,784.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: NIGMS
Solicitation Number: PA11-096
Small Business Information
400 Sagner Avenue, Suite 300, FREDERICK, MD, 21701-6082
DUNS: 154704444
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (301) 698-0101
Business Contact
Phone: (301) 698-0101
Email: cooney@akonni.com
Research Institution
DESCRIPTION (provided by applicant): Sample preparation frequently presents a bottleneck for clinical molecular biology workflows. Whereas there are many readout detection modalities, there are only a handful of automated sample preparation workflow strategies. Existing instruments that are built around these sample preparation strategies and chemistries range in cost from 17- 150k, and yet they still do not include an integrated method of lysing difficult-to-disrupt organisms such as gram-positive bacteria or the acid fast bacilli (i.e., Mycobacterium). To address these limitations, we propose to integrate Akonni's sample preparation technologies into a low-cost automated instrument that can process a variety of sample types such as blood, nasopharyngeal swabs, and nasopharyngeal aspirate with a simple-to-use consumable kit. PUBLIC HEALTH RELEVANCE: Molecular diagnostics, which are tests that analyze the DNA and/or RNA in a sample, are becoming increasingly prevalent among clinical laboratory testmethods. An important, yet challenging, procedure, required of these tests, is to remove the DNA/RNA from the sample and wash away the impurities. We seek to develop a low-cost automated instrument to address this challenge

* Information listed above is at the time of submission. *

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government