Rapid Field Test for Iodine Levels in Salt

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$149,985.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
1R43HD069159-01A1
Award Id:
n/a
Agency Tracking Number:
R43HD069159
Solicitation Year:
2012
Solicitation Topic Code:
NICHD
Solicitation Number:
PA11-096
Small Business Information
2501 Earl Rudder Freeway South, COLLEGE STATION, TX, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
184758308
Principal Investigator:
BIKAS VAIDYA
(979) 764-2200
bikas.vaidya@lynntech.com
Business Contact:
G HISAW
(979) 764-2218
renee.hisaw@lynntech.com
Research Institution:
Stub




Abstract
DESCRIPTION (provided by applicant): Iodine deficiency is the single most common cause of preventable mental retardation and brain damage in the world. It also decreases child survival, causes goiters, and impairs growth and development. Iodine deficiencyin pregnant women causes miscarriages, stillbirths, and other complications. Children with iodine deficiency disorder (IDD) can grow up stunted, mentally retarded, and incapable of normal movements, speech, or hearing. Globally, 2.2 billion people (38% ofthe world's population) live in areas with iodine deficiency and risk its complications. Iodine deficiency and the problems it causes can be prevented by use of iodized salt and effective monitoring of iodine nutrition. However, the level of iodization ofsalt should be carefully regulated as inadequate levels in the diet will have no noticeable benefit, while excessive doses are wasteful, and may actually result in detrimental health effects. A reliable, simple, and rapid method is therefore needed for routine monitoring of iodine levels in iodized salt at the manufacturing, distribution, retail and household levels. Currently available methods for determination of iodine levels in salt (e.g. colorimetry, classical titration, flow injection analysis, ionchromatography, and ICP-MS) are either not sufficiently sensitive and/or are laborious, require use of highly corrosive chemicals and/or require specialized and expensive equipment, and therefore are not suitable for field testing. To address this need, Lynntech is proposing to develop a simple innovative method for rapid and accurate measurement of iodine levels in salt, suitable for field testing. This method will utilize convenient, disposable, dry reagent cartridges for sample conditioning and iodine level determination and eliminates the need for use of highly corrosive liquid reagents. To determine the iodine content of a salt sample by Lynntech's method, one will simply dissolve a salt sample in water, pass the solution through the cartridge, and take the reading. During Phase I of the project Lynntech will demonstrate the feasibility of using this innovative method being developed at Lynntech for rapid and accurate determination of iodine level in salt through successful achievement of the followingobjectives: i). Demonstrate that iodide from iodized salts can be oxidized to iodine using a dried oxidizing agent; ii). Demonstrate that iodate from iodized salts can be reduced to iodine using a dried reducing agent; iii). Demonstrate that the iodine released from the iodized salts can be determined quantitatively by the proposed colorimetric method. PUBLIC HEALTH RELEVANCE: Iodine deficiency and the problems it causes can be prevented by use of iodized salt and effective monitoring of iodine nutrition. Currently available methods for determination of iodine level in salt are either not sufficiently sensitive and/or are laborious, require use of highly corrosive chemicals and/or require specialized and expensive equipment, and therefore, are notsuitable for field applications. Lynntech is proposing to develop a simple and accurate method using disposable cartridges for routine monitoring of iodine levels in iodized salt in the field.

* information listed above is at the time of submission.

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