An Innovative Cardioprotective

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$373,934.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
1R43HL114298-01
Award Id:
n/a
Agency Tracking Number:
R43HL114298
Solicitation Year:
2012
Solicitation Topic Code:
NHLBI
Solicitation Number:
PA11-096
Small Business Information
51 Charles Lindbergh Blvd, Uniondale, NY, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
53129065
Principal Investigator:
PRAKASH NARAYAN
(516) 326-1200
pnarayan@angion.com
Business Contact:
ITXHAK GOLDBERG
(516) 326-1200
igoldberg@angion.com
Research Institution:
Stub




Abstract
DESCRIPTION (provided by applicant): Myocardial infarction (MI) is a significant cause of morbidity and mortality in the U.S. H2 Relaxin (H2R) is a Phase III clinical trial-stage peptide that exhibits both anti-inflammatory and cytoprotective activities which can potentially be harnessed for the treatment of MI via use as adjuvant to recanalization therapy. However, clinical administration of rhH2R is not only prohibitively expensive but also plagued by numerous logistical issues. To fully capitalize on thetherapeutic potential of the H2R pathway while overcoming the afore-mentioned shortcomings, Angion Biomedica Corp. has developed a library of chemically synthesizable H2R-like peptides. In preliminary studies, ANG-4011, our lead H2R-like peptide demonstrated significant tissue protective effects. The present Phase 1 SBIR proposal is designed to fully optimize the therapeutic effects of ANG-4011 in experimental myocardial ischemia-reperfusion injury. Data from this program will form the basis for a comprehensive SBIR Phase II program goals for which include optimization of ANG-4011 delivery in sustained-release, clinically compatible, biodegradable microspheres, evaluation of ANG-4011 therapy in myocardial-reperfusion models accompanied by co-morbidities (e.g. age and diabetes) and ANG-4011 safety/toxicology evaluation. The overall objective of this program is to bring potentially promising therapeutic to clinical trials for patients presenting with MI. PUBLIC HEALTH RELEVANCE: Myocardial infarctionremains a significant cause of morbidity and mortality. A cardioprotective agent that reduces infarct size and salvages myocardium can avert the transition to pump failure.

* information listed above is at the time of submission.

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