Encapsulated Lipid Bilayer Based Assay for Assessing Botulinum Neurotoxin Potency

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$184,864.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
1R43NS074610-01A1
Award Id:
n/a
Agency Tracking Number:
R43NS074610
Solicitation Year:
2012
Solicitation Topic Code:
NINDS
Solicitation Number:
PA09-179
Small Business Information
5754 PACIFIC CENTER BLVD, #204, SAN DIEGO, CA, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
129852864
Principal Investigator:
ERIC ERVIN
(858) 412-1705
ervin@electronicbio.com
Business Contact:
MELISSA POQUETTE
(858) 412-1705
mpoquette@electronicbio.com
Research Institution:
Stub




Abstract
DESCRIPTION (provided by applicant): Unknown or poorly understood differences in the potency of therapeutics containing the botulinum neurotoxin Type A (BoNT/A) could result in over or under dosing of patients. The potency of BoNT/A therapeutics is currently assessed using a mouse intraperitoneal injection assay. However, due to the fact that this assay relies on the use of animals, and has an inherently high error rate due to the variability in the sensitivityof different mouse species and test conditions,a new standardized assay is needed. Electronic BioSciences proposes to develop a BoNT/A potency assay based on electrophysiological planar lipid bilayer techniques. This assay will utilize a reader and associated lipid bilayer based disposable cartridgefor examining the functionality of the toxin in a given sample, and determining that samples potency. The proposed system will be able to assess the potency of a BoNT/A therapeutic with high accuracy at a low cost. PUBLIC HEALTH RELEVANCE: The proposed system will be used for assessing the potency of a therapeutic containing botulinum neurotoxin Type A (BoNT/A). The system is proposed as a standardized, low-cost, higher-accuracy alternative to the mouse intraperitoneal injection assay currently being used by BoNT/A researchers and manufactures.

* information listed above is at the time of submission.

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