IGF::OT::IGF OTHER FUNCTIONS TOPIC 267, MULTIFUNCTIONAL THERAPEUTICS USING ENGINEERED PLANT VIRUS NANOPARTICLES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$1,199,956.00
Award Year:
2012
Program:
SBIR
Phase:
Phase II
Contract:
N44CO120038
Award Id:
n/a
Agency Tracking Number:
N44CO120038
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
PO BOX 98385, RALEIGH, NC, 27624-8385
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
825302644
Principal Investigator:
BRUCEOBERHARDT
(919) 848-6520
BOBERHARDT@NANOVECTORINC.COM
Business Contact:
BRUCEOBERHARDT
(919) 848-6520
BOBERHARDT@NANOVECTORINC.COM
Research Institute:
Stub




Abstract
A biologic nanoparticle is the basis of this proposal. The plant virus nanoparticle (PVN) is based on a virus that: exists in the human food chain; is nontoxic and of low immunogenicity; can load medical imaging agents and/or therapeutic drugs into itscargo chamber by a simple process; and can be engineered to identify and enter cancer cells and release drug payloads inside cell structures, such as the nucleus where most anticancer drugs operate, bypassing most cancer cell defenses. It has a highly evolved sensor/actuator system to release cargo only in the targeted cell. In this Phase II project, NanoVector, Inc. will: perform mouse pharmacology studies and efficacy studies using human melanoma xenografts; increase PVN production efficiency and scalability; perform long term toxicity studies with biodistribution and bioelimination data, as well as early IND enabling studies, and initiation of large animal studies.

* information listed above is at the time of submission.

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