Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N44CO120043
Agency Tracking Number: N44CO120043
Amount: $1,000,000.00
Phase: Phase II
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: NCI
Solicitation Number: N/A
Small Business Information
DUNS: 102861262
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (512) 996-8833
Business Contact
Phone: (512) 996-8833
Research Institution
Label-free, highly sensitive early cancer detection sensors with required specificity are in great demand. In Phase 1, we experimentally confirmed feasibility of our proposed photonic crystal (PC) microarray with real data better than all reported sensing methods. These include absolute biomolecule mass sensitivity 8.8attograms (10A-18grams), surface mass sensitivity 0.8picogram (10A-12grams)/mmA2 in a sensing area 5.7micronA2. We demonstrated sensing capability of 72 binding reactions between a targetand its conjugate probe biomolecule simultaneously, at the same time with 60 microliters total probe sample volume. We detected lung cancer ceillysates with specificity by sandwich assay. In Phase 2, all demonstrated components for chip integrated microarray will be integrated with antibodies detecting lung and breast cancer cell Iysates with high sensitivity, specificity and throughput via committed collaborations with Medical University of South Carolina and MD Anderson Cancer Center. The device has biomolecule functionalized PC microcavity resonator arrays coupled to a PC waveguide, further arrayed using multimode interference splitters, which transduce specific binding between probe and target biomolecules. Our multi-analyte sensing has applications in drug discovery, food feedstock assays and biD-warfare defense. Silicon CMOS compatibility ensures mass manufacturability with at least one order of magnitude better cost of ownership than any existing approach

* Information listed above is at the time of submission. *

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