OTHER FUNCTIONS PHASE 0 CARBOPLATIN MICRODOSING DIAGNOSTIC TRIAL.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N44CO120048
Agency Tracking Number: N44CO120048
Amount: $1,499,894.00
Phase: Phase II
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: NCI
Solicitation Number: N/A
Small Business Information
ACCELERATED MEDICAL DIAGNOSTICS, LLC
ACCELERATED MEDICAL DIAGNOSTICS, LLC, DAVIS, CA, 95616-5472
DUNS: 826929015
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 PAUL HENDERSON
 (925) 570-1615
 HENDERSON48@GMAIL.COM
Business Contact
 PAUL HENDERSON
Phone: (925) 570-1615
Email: HENDERSON48@GMAIL.COM
Research Institution
 Stub
Abstract
We developed a technology called PlatinDx that, based upon preclinical data, can potentially identify chemoresistance in lung and bladder cancer patients before they receive carboplatin therapy. PlatinDx utilizes tracing of subtherapeutic microdoses of14C-labeled carboplatin with accelerator mass spectrometry (AMS), which has attomole (10-18 mole) sensitivity for 14C. We hypothesize that DNA damage caused by a single subtoxic microdose of carboplatin can predict patient outcomes such as tumor shrinkage, progression free survival and toxicity. The goal of the project is to test the clinical feasibility of PlatinDx in bladder and lung cancer patients. The PlatinDx data will be compared to ERCC1 expression using the Response Genetics RT-PCR assay as a benchmark. The resulting feasibility data will allow the design of a Pivotal Trial, which is required for FDA clearance and product launch.

* information listed above is at the time of submission.

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