IGF::OT::IGF OTHER FUNCTIONS TOPIC 276- CHEMOLIEVE: DIFFERENTIAL PROTECTION OF NORMAL VERSUS CANCER CELLS IN PATIENTS RECIEVING CHEMOTHERAPY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$1,499,963.00
Award Year:
2012
Program:
SBIR
Phase:
Phase II
Contract:
N44CO120051
Award Id:
n/a
Agency Tracking Number:
N44CO120051
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
3975 Landmark St Ste 500, Cuvler City, CA, 90232
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
829663124
Principal Investigator:
TODDMORGAN
(310) 662-1205
TMORGAN@L-NUTRA.COM
Business Contact:
TODDMORGAN
(310) 662-1205
TMORGAN@L-NUTRA.COM
Research Institute:
Stub




Abstract
This solicited Phase II proposal builds on L-Nutra s successful Phase I results which identified a dietary formulation (Chemolieve) that protects mice against the toxicity of chemotherapy drugs and retards the growth of cancer masses while enhancing the efficacy of chemotherapy. The proposed Phase II studies include aims to provide the necessary pre-clinical evidence to determine the efficacy of Chemolieve in protecting normal cells but sensitizing the most common tumors to standard chemotherapy drugs in mouse models. Another goal is to characterize the effect of Chemolieve on DNA damage and mutagenesis caused by chemotherapy to both normal and cancer cells. Also proposed is a clinical trial to test the safety of Chemolieve and its role in reducing the sideeffects and increasing the efficacy of the standard chemotherapy cocktail adopted for breast cancer treatment. In summary, these studies can: (1) demonstrate that Chemolieve is effective in improving the therapeutic index of a wide variety of chemotherapydrugs on the most common tumors; and (2) demonstrate clinically that Chemolieve can be effective in support of the standard chemotherapy used to treat breast cancer. A positive outcome for these studies will allow L-Nutra to begin sales of Chemolieve.

* information listed above is at the time of submission.

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