IGF::OT::IGF OTHER FUNCTIONS DEVELOPMENT OF A UNI-DIRECTIONAL BRACHYTHERAPY DEVICE FOR THE TREATMENT OF NON-SMALL-CELL LUNG CANCER

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N44CO120052
Agency Tracking Number: N44CO120052
Amount: $998,964.00
Phase: Phase II
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: NCI
Solicitation Number: N/A
Small Business Information
CIVATECH ONCOLOGY, INC.
CIVATECH ONCOLOGY, INC., RESEARCH TRIANGLE PARK, NC, 27709-
DUNS: 801431862
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 KRISTY PEREZ
 (919) 314-5515
 KPEREZ@CIVATECHONCOLOGY.COM
Business Contact
 KRISTY PEREZ
Phone: (919) 314-5515
Email: KPEREZ@CIVATECHONCOLOGY.COM
Research Institution
 Stub
Abstract
According to the American Cancer Society 220,000 men and women in the U.S. develop lung and bronchial cancer every year and 147,000 die of the disease. Of lung cancer patients, 85% present with non-small-cell lung cancer and 16.7% of these will present with localized disease. Note that lung cancer is very difficult to treat. The five year survival for localized disease is 52%, the five year survival for more advanced disease is less than 24%. At present, brachytherapy devices used for lung cancer treatmentconsist of metal I-125 or Cs-131 seeds, originally designed for prostate cancer, sewn to a bio-absorbable vicryl mesh. The device is not optimal for treating lung cancer. The device emits radiation in all directions and delivers radiation to otherwise healthy tissue. It is cumbersome to handle and difficult to shape to the patient s anatomy. Lung tumors are often located near critical structures sensitive to radiation exposure. Approximately 20% of patients who otherwise could be treated with lung brachytherapy are either not treated or prescribed alternative treatments due to the risk of radiation exposure to the arteries, nerves, the heart, the chest wall, the skin, and in female patients, the breasts. Those patients who are treated with the existing device are exposed to unnecessary radiation dose. CivaTech developed, with partial support from a Phase I SBIR contract from the National Cancer Institute, a prototype brachytherapy device specifically designed for lung cancer treatment that directions radiation therapy to diseased tissue only. This device, called the CivaSheet, is planar, uni-directional and partially bio-absorbable. CivaTech is seeking Phase II support to develop the prototype into a clinic ready device.

* information listed above is at the time of submission.

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