OTHER FUNCTIONS TOPIC 255, PHASE II, TARGETED TWO-PHOTON PHOTODYNAMIC THERAPY TRIADS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$1,499,896.00
Award Year:
2012
Program:
SBIR
Phase:
Phase II
Contract:
N44CO120093
Award Id:
n/a
Agency Tracking Number:
N44CO120093
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
920 Technology Blvd, BOZEMAN, MT, 59718-
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
Y
Duns:
141315882
Principal Investigator:
CHARLESSPANGLER
(406) 587-6338
CHARLES.SPANGLER@SENSOPATH.COM
Business Contact:
CHARLESSPANGLER
(406) 587-6338
CHARLES.SPANGLER@SENSOPATH.COM
Research Institute:
Stub




Abstract
The objectives of this proposal are to further preclinical development of unique two-photon-activated photodynamic therapy (TPPDT) triads that incorporate a nontoxic porphyrin photosensitizer, a tumor targeting group, and an imaging functionality, providing for noninvasive image-guided treatment of recurrent and refractory head and neck tumors deep below the skin surface that currently have low survival rates and few treatment options. SensoPath Technologies will develop a detailed understanding of the dosimetry of the process, involving the interplay of targeting the receptor on the tumor surface, the delivery of pulsed near infrared (NIR) laser light in the range 800-840 nm, the method of drug delivery with optimized concentration, and the role of oxygen level in the tumor s blood supply. Image-guided TPPDT, in which the irradiation of the tumor is controlled by its digitized image throughout the 3D volume of the tumor, will define and incorporate optical tumor margins to ensure that the entire tumor is treated. Planned image-defined tumor treatment in tissue phantoms and xenograft SCID mouse models will provide the information necessary to effectively treat deep spontaneous head and neck tumors in companion canines as an out-patient low-cost model for humanclinical treatment with rapid recovery, little scarring and no post-PDT light sensitivity.

* information listed above is at the time of submission.

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