OTHER FUNCTIONS - RECOMBINANT ANTIBODIES AS AFFINITY CAPTURES

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N44HV120047
Agency Tracking Number: N44HV120047
Amount: $990,779.00
Phase: Phase II
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: NHLBI
Solicitation Number: N/A
Small Business Information
AVANTGEN, INC., SAN DIEGO, CA, 92129-4571
DUNS: 186489899
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 XIAOMIN FAN
 (858) 768-8107
 XFAN@AVANTGEN.COM
Business Contact
 XIAOMIN FAN
Phone: (858) 768-8107
Email: XFAN@AVANTGEN.COM
Research Institution
 Stub
Abstract
One of the biggest roadblocks to the translation of basic proteomic discoveries to potential clinical applications is the lack of robust and sensitive reagents that can capture a given protein reproducibly from different types of matrixes. While antibodieshave been the major players of protein capture, alternate reagents are urgently needed to overcome the lack of sensitivity, specificity, and reproducibility associated with many of the current antibodies to help translate cardiovascular protein biomarkerdiscoveries into clinical utility. Development of sensitive, well characterized, reproducible and cost effective reagents that can capture proteins involved in cardiovascular physiology or pathology would greatly benefit the cardiovascular research community. The goal of this contract is to generate high affinity antibodies against a panel of cardiovascular markers using a proprietary yeast display antibody library system.

* Information listed above is at the time of submission. *

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