OTHER FUNCTIONS - A NOVEL TUMOR PAINT FOR TUMOR RESECTION

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$248,551.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
N43CO120054
Award Id:
n/a
Agency Tracking Number:
N43CO120054
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
BLAZE BIOSCIENCE, INC., 530 FAIRVIEW AVE N, STE 1000, SEATTLE, WA, 98109-7601
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
968653605
Principal Investigator:
JULIAPARRISH
(206) 849-3647
JULIE.NOVAK@BLAZEBIOSCIENCE.COM
Business Contact:
JULIAPARRISH
(206) 849-3647
JULIE.NOVAK@BLAZEBIOSCIENCE.COM
Research Institute:
Stub




Abstract
Tumor Paints for real-time intraoperative visualization of solid tumors enable more complete resection while sparing surrounding normal tissue. For brain tumors this is of paramount importance, since removal of additional tissue can unnecessarily increasecognitive and functional impairment. The Tumor Paint CyTP007 is a peptide-fluorophore conjugate that specifically binds to multiple solid tumor types and fluoresces in the near-infrared range, minimizing light scatter and signal attenuation. Our overall long-term objectives are to determine the effective dose of CyTP007 for imaging during tumor resections (Phase 1), and to evaluate candidate intraoperative imaging devices (Phase 2). The proposed Phase 1 study is a dose-ranging study in dogs with solid tumors. Dogs undergoing tumor resection will receive CyTP007 intravenously 24 hours before surgery, and tissue will be imaged ex vivo after surgery. Specific aims: (1) Assess tolerability in the context of general anesthesia and surgery; (2) Determine optimal dose for imaging canine tumors; (3) Quantitate fluorescence in tumors; and (4) Assess specificity for cancer cells and signal-to-background ratio. Anticipated results include safety at an effective imaging dose; signal intensity in different tumor types; confirmation that CyTP007 penetrates the blood-brain barrier; and sensitivity and specificity for discrimination of cancer from normal cells.

* information listed above is at the time of submission.

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