IGF::OT::IGF OTHER FUNCTIONS RandD- MEDICAL: BIOMEDICAL (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N43CO120059
Agency Tracking Number: N43CO120059
Amount: $249,525.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: NCI
Solicitation Number: N/A
Small Business Information
7700 RIVERS EDGE DRIVE, COLUMBUS, OH, 43235-
DUNS: 790552264
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 THOMAS ZUPANCIC
 (614) 888-9220
 TZUPANCIC@YAHOO.COM
Business Contact
 THOMAS ZUPANCIC
Phone: (614) 888-9220
Email: TZUPANCIC@YAHOO.COM
Research Institution
 Stub
Abstract
Surgical resection of malignant tumors is the single most effective therapy for cancer. Long-term patient outcomes are strongly determined by the extent to which the surgeon can completely remove all diseased tissues. Present cancer imaging and detectionmethods often fail to provide a clear picture of the extent of disease. SPECT (single photon emission computed tomography) is a sizeable market with a large installed base of scanners. SPECT has not adequately been supported for use in cancer imaging.Recent developments SPECT/CT fused imaging technology with attenuation correction alter this picture. Enlyton proposes to develop and test a series of tunable antibody targeting compounds for SPECT imaging of adenocarcinoma (e.g., colorectal, pancreatic, gastric, esophageal, lung) in cancer patients. It is an aim of this proposal to construct specific antibody targeting compositions that can rapidly accumulate in tumors while clearing from circulation quickly. It is a further aim to validate in vivo the efficacy of the preferred single chain antibody configuration, and optimize the time to SPECT/CT imaging. The modified tumor targeting agent will be labeled with an appropriate radioisotope (123I) to enable dosing and imaging within 24 hours usingexisting SPECT and SPECT/CT imaging platforms.

* Information listed above is at the time of submission. *

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