IGF::OT::IGF OTHER FUNCTIONS GENOME PHASE I, TOPIC 309, LABEL FREE MULTIVARIATE CANCER DIAGNOSIS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$199,987.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
N43CO120070
Agency Tracking Number:
N43CO120070
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
GENOME DATA SYSTEMS, INC.
127 US HIGHWAY 206, STE 29, HAMILTON, NJ, 99999-
Hubzone Owned:
N
Socially and Economically Disadvantaged:
Y
Woman Owned:
N
Duns:
003105033
Principal Investigator:
RAJAN KUMAR
(609) 581-6861
RKUMAR@GENOMEDATASYSTEMS.COM
Business Contact:
RAJAN KUMAR
(609) 581-6861
RKUMAR@GENOMEDATASYSTEMS.COM
Research Institution:
Stub




Abstract
Breast cancer is a leading cause of malignancies in women, resulting in almost 200,000 new cases every year. In approximately one third of breast cancer patients, malignant cells spread to distant organs and cause metastatic tumors. Tumor progression, metastatic spread and patient prognosis depends on proteins present in cancerous cells. A number of proteins whose over-activation and impaired down-regulation have been implicated in these processes have been identified by recent studies. For example, over-expression of cell surface proteins - EGFR and ERBB2 (her2-neu) is correlated with a more aggressive breast cancer phenotype and a poor patient prognosis. In addition, during development of drug resistance, breast cancer cells over-express several cell surface proteins such as FGFR3. Therefore, analysis of cell surface proteins provides an excellent opportunity to diagnose breast cancer and predict prognosis and treatment outcomes. However, technologies for highly sensitive and specific multiplexed analysis of cell surface proteins at the single cell level are limited. In this project, we propose to further develop a novel technology for the analysis of as many as 30 cell surface proteins at a single cell level to achieve accurate breast cancer diagnosis, andpredict therapeutic response and patient outcome rapidly and at a low cost.

* information listed above is at the time of submission.

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