IGF::OT::IGF OTHER FUNCTIONS RandD- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N43CO120078
Agency Tracking Number: N43CO120078
Amount: $197,224.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: NCI
Solicitation Number: N/A
Small Business Information
1550 UTICA AVE. S., SUITE 770, MINNEAPOLIS, MN, 55416
DUNS: 197085517
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MICHAEL KAYTOR
 (952) 400-0404
 MKAYTOR@HUMANETICSCORP.COM
Business Contact
 MICHAEL KAYTOR
Phone: (952) 400-0404
Email: MKAYTOR@HUMANETICSCORP.COM
Research Institution
 Stub
Abstract
Lung cancer is the most common cause of cancer-related deaths in the United States. Humanetics will develop BIO 300 as a drug that can be given with radiotherapy for lung cancer to help improve efficacy and to decrease toxicity. The focus of the development will be with non-small cell lung cancers where BIO 300 has already shown an ability to inhibit cancer growth. BIO 300 also has a demonstrated ability to protect normal tissues exposed to radiation. In Phase I of this proposal, we will complete a series of mouse efficacy studies assessing BIO 300 s ability to inhibit tumor growth in an A549 xenograft non-small cell lung cancer model as well as evaluating the effects on normal tissues. In Phase II we will use the research results of the Phase I experiments along with the existing BIO 300 safety data to file an IND for the use of BIO 300 in patients receiving radiotherapy for non-small cell tumors of the lung. Once FDA clearance is obtained we will proceed with a clinical study to assess the safety andeffect of BIO 300 in improving the morbidity and mortality in patients receiving radiation therapy for non-small cell lung cancer.

* Information listed above is at the time of submission. *

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