IGF::OT::IGF OTHER FUNCTIONS RandD- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$197,224.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
N43CO120078
Award Id:
n/a
Agency Tracking Number:
N43CO120078
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
1550 UTICA AVE. S., SUITE 770, MINNEAPOLIS, MN, 55416
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
197085517
Principal Investigator:
MICHAEL KAYTOR
(952) 400-0404
MKAYTOR@HUMANETICSCORP.COM
Business Contact:
MICHAEL KAYTOR
(952) 400-0404
MKAYTOR@HUMANETICSCORP.COM
Research Institution:
Stub




Abstract
Lung cancer is the most common cause of cancer-related deaths in the United States. Humanetics will develop BIO 300 as a drug that can be given with radiotherapy for lung cancer to help improve efficacy and to decrease toxicity. The focus of the development will be with non-small cell lung cancers where BIO 300 has already shown an ability to inhibit cancer growth. BIO 300 also has a demonstrated ability to protect normal tissues exposed to radiation. In Phase I of this proposal, we will complete a series of mouse efficacy studies assessing BIO 300 s ability to inhibit tumor growth in an A549 xenograft non-small cell lung cancer model as well as evaluating the effects on normal tissues. In Phase II we will use the research results of the Phase I experiments along with the existing BIO 300 safety data to file an IND for the use of BIO 300 in patients receiving radiotherapy for non-small cell tumors of the lung. Once FDA clearance is obtained we will proceed with a clinical study to assess the safety andeffect of BIO 300 in improving the morbidity and mortality in patients receiving radiation therapy for non-small cell lung cancer.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government