OTHER FUNCTIONS - RandD BIOMEDICAL (BASIC RESEARCH)

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$215,999.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
N43CO120082
Agency Tracking Number:
N43CO120082
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
ZONEONE PHARMA, INC.
QB3, 1700 4TH STREET, STE 214, SAN FRANCISCO, CA, 94158-
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
968317870
Principal Investigator:
CHARLES NOBLE
(415) 476-9792
CNOBLE@ZONEONEPHARMA.COM
Business Contact:
CHARLES NOBLE
(415) 476-9792
CNOBLE@ZONEONEPHARMA.COM
Research Institution:
Stub




Abstract
The Hsp90 inhibitor 17-DMAG will be encapsulated in a nano-sized liposome formulation that is long-circulating with controlled drug release properties in tumor tissue. Reformulation of 17-DMAG in a nanoliposome will increase the dose intensity of 17-DMAG in solid tumors while reducing the hepatic, gastrointestinal, nausea and bone marrow toxicity. The key is devising a nanoliposome composition that will retain the drug in circulation and release the drug from the nanoliposome at an appropriate rate after accumulation in the tumor. ZoneOne Pharma will use a new class of sterol-modified lipids (SML) that enable a wide and predictable range of drug release rates from the nanoliposome to encapsulate 17-DMAG using a remote loading protocol. In this development plan, ZoneOne Pharma will design nanoliposome compositions of 17-DMAG for evaluation by loading efficiency, in vitro plasma stability, in vivo pharmacokinetic and biodistribution studies. These formulations will be evaluated for tumor release effect on therapeutic activity in a proof-of-concept efficacy study at the end of Phase 1. A single formulation will be selected from confirmation efficacy studies as the first step of a future Phase II project.

* information listed above is at the time of submission.

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