IGF::OT::IGF OTHER FUNCTIONS - RandD BIOMEDICAL (BASIC RESEARCH)

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$187,222.00
Award Year:
2012
Program:
SBIR
Phase:
Phase I
Contract:
N43CO120083
Agency Tracking Number:
N43CO120083
Solicitation Year:
2012
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
INTEZYNE TECHNOLOGIES, LLC
INTEZYNE TECHNOLOGIES, INC., 3720 SPECTRUM BLVD, STE 104, TAMPA, FL, 33612-
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
002002948
Principal Investigator:
KEVIN SILL
(813) 910-2120
KEVIN.SILL@INTEZYNE.COM
Business Contact:
KEVIN SILL
(813) 910-2120
KEVIN.SILL@INTEZYNE.COM
Research Institution:
Stub




Abstract
This project aims to develop a stabilized epothilone B (Epo B)-loaded micelle for the intravenous delivery of Epo B to solid tumors. The data should demonstrate that Epo B is encapsulated within the micelle with weight-loadings in the range of 1-5% wt/wt Epo B. Crosslinking chemistries will be applied to Epo B-loaded micelles to generate a crosslinked, stabilized, Epo B micelle. It is anticipated that the particle size of micelles will be between 30-100nm. Based on previous studies with iron-crosslinked micelles, pH-dependent release of Epo B is expected in vitro. Crosslinked Epo B micelles are also expected to be more stable in serum than un-crosslinked micelles, in vitro. Administration of crosslinked micelles to cancer cells in vitro should exhibit similar if not identical cytotoxicity as free Epo B. In vivo characterization should result in: (a) determination of the maximum tolerated dose (MTD) of the Epo B micelle in nude mice; (b) the pharmacokinetics of the Epo B micelle compared to free Epo B in nudemice; and (c) the antitumor efficacy of the micelle in two xenograft models. It is anticipated that the Epo B micelle will outperform free drug in terms of having a higher MTD, superior pharmacokinetics, and improved antitumor efficacy compared to free EpoB.

* information listed above is at the time of submission.

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