IGF::OT::IGF OTHER FUNCTIONS TAS:: 750849 REFORMULATION OF CANCER THERAPEUTICS USING NANOTECHNOLOGY

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N43CO120092
Agency Tracking Number: N43CO120092
Amount: $191,326.00
Phase: Phase I
Program: SBIR
Awards Year: 2012
Solicitation Year: 2012
Solicitation Topic Code: NCI
Solicitation Number: N/A
Small Business Information
LIPOMEDICS LTD
LIPOMEDICS, LIMITED COMPANY, 4340 WEDGWORTH CT, FORT WORTH, TX, 76133-
DUNS: 100424055
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 WALTER MCCONATHY
 (432) 212-2416
 MC123@ATT.NET
Business Contact
 WALTER MCCONATHY
Phone: (432) 212-2416
Email: MC123@ATT.NET
Research Institution
 Stub
Abstract
The aim of this project is to reformulate a highly lipophilic anti-cancer agent, valrubicin (AD-32) that has only been approved for vesicular treatment of bladder cancer due to its poor dose limiting toxicities due to poor water solubility. LipoMedics willreformulate valrubicin (AD-32) utilizing a robust, novel biocompatible drug delivery system, composed of reconstituted high density lipoprotein (rHDL) nanoparticles that are particularly effective in improving solubility and safety of poorly soluble drugs. The additional advantage of formulating drugs with rHDL is the selective targeting toward malignant tumors via the SR-B1 receptor. LipoMedics intends to conduct proof of concept studies to evaluate therapeutic efficacy of the rHDL/AD-32 drug formulationversus that of the free drug. These studies will include assessment of cytotoxicity versus cancer cells, stability of the rHDL/AD-32 formulation and tumor suppression studies in mice. The major goal of these studies is to demonstrate enhancement in therapeutic efficacy of AD-32 via encapsulation in rHDL nanoparticles. Based on previous studies, it is anticipated that AD-32, as an initial model, and subsequently a wide range of similarly lipophilic drugs, can be reformulated to produce clinically effective anti-cancer drugs as well as profitable ventures for biotech entrepreneurs.

* information listed above is at the time of submission.

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