490 BIOTECH INC

Basic Information

2450 EJ CHAPMAN DR
KNOXVILLE, TN, 37996-0001

http://www.490biotech.com

Company Profile

490 BioTech is a life sciences company that develops patent protected autonomously light-emitting (autobioluminescent) human and animal cell lines genetically programmed to ‘report’ on biological events or interactions that affect their metabolic status in real time. The incorporation of these cell lines into cell culture and small animal preclinical efficacy/toxicity testing models accelerates the pace of new drug discovery by moving drugs more rapidly and more effectively towards Phase I human testing with a reduced overall cost.

Additional Details

Field Value
DUNS: 968832498
Hubzone Owned: Y
Socially and Economically Disadvantaged: N
Woman Owned: N
Number of Employees: 8


  1. An improved bioassay for the surveillance of dioxins in the U.S. food supply

    Amount: $99,551.00

    Dioxin and other dioxin-like chemicals are persistent environmental pollutants that threaten human and animal health due to their stability in the environment and their ability to accumulate in the fo ...

    SBIR Phase I 2015 Department of Agriculture
  2. Expressing humanized bacterial luciferase in stem cells: Moving beyond firefly luciferase to expand the informational capacity of animal models for regenerative medicine

    Amount: $149,960.00

    DESCRIPTION provided by applicant This Small Business Technology Transfer STTR Phase I project proposes to develop autonomously bioluminescent human stem cells for continuous reagent free and r ...

    STTR Phase I 2015 Department of Health and Human Services National Institutes of Health
  3. Expanding the throughput of real-time toxicological screening of cardiac differentiation by expressing a synthetic luciferase/luciferin genetic pathway in iPSCs

    Amount: $224,924.00

    DESCRIPTION provided by applicant Expanding the throughput of real time toxicological screening of cardiac differentiation by expressing a synthetic luciferase luciferin genetic pathway in iPSCs Pr ...

    SBIR Phase I 2015 Department of Health and Human Services National Institutes of Health
  4. Development of a high-throughput screen to detect the effects of both pre- and post-biotransformed compounds for enhanced content drug discovery workflows

    Amount: $149,051.00

    DESCRIPTION provided by applicant Development of a high throughput screen to detect the effects of both pre and post biotransformed compounds for enhanced content drug discovery workflows Projec ...

    SBIR Phase I 2015 Department of Health and Human Services National Institutes of Health
  5. Expressing bacterial bioluminescence in human cell lines: Engineering autobioluminescent reporter cells to screen for endocrine disruptor chemicals

    Amount: $538,007.00

    DESCRIPTION provided by applicant Expressing bacterial bioluminescence in human cell lines Engineering autobioluminescent reporter cells to screen for endocrine disruptor chemicals Project Summar ...

    SBIR Phase II 2015 Department of Health and Human Services National Institutes of Health
  6. SBIR Phase I: Expressing bacterial luciferase in zebrafish as an innovative new tool for data-intensive, higher-throughput drug discovery

    Amount: $150,000.00

    This Small Business Innovation Research (SBIR) Phase I project proposes to develop self-generated bioluminescence in zebrafish to create improved models for new drug discovery, therapeutic testing, an ...

    SBIR Phase I 2014 National Science Foundation
  7. Expressing bacterial bioluminescence in human cell lines: Engineering autobiolumi

    Amount: $138,191.00

    DESCRIPTION (provided by applicant): Expressing bacterial bioluminescence in human cell lines: Engineering autobioluminescent reporter cells to screen for endocrine disruptor chemicals Project Summary ...

    SBIR Phase I 2013 Department of Health and Human Services

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